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Peony and liquorice soup formula granule, preparation method and detection method of peony and liquorice soup formula granule

A technology of Shaoyao Gancao Decoction and formula granules, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, antipyretics, etc., can solve the problems of Shaoyao Gancao Decoction formula granules that cannot be used safely and the quality cannot be well controlled.

Inactive Publication Date: 2013-10-02
KANGMEI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Therefore, the object of the present invention is to provide a Shaoyao Gancao Decoction formula granule and its preparation method and detection method in view of the shortcomings that the Shaoyao Gancao Decoction formula granules in the prior art cannot be used safely and the quality cannot be well controlled. The Shaoyao Gancao Decoction Formula Granules have few side effects and can be used more safely through this detection method

Method used

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  • Peony and liquorice soup formula granule, preparation method and detection method of peony and liquorice soup formula granule
  • Peony and liquorice soup formula granule, preparation method and detection method of peony and liquorice soup formula granule
  • Peony and liquorice soup formula granule, preparation method and detection method of peony and liquorice soup formula granule

Examples

Experimental program
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Effect test

Embodiment 1

[0084] Preparation of Example 1 Shaoyao Gancao Decoction Formula Granules

[0085] 1. Source of medicinal materials

[0086] See Table 1 for source and place of origin

[0087] Table 1 sources of medicinal materials

[0088]

[0089] 2. Instruments and equipment

[0090] Midea Induction Cooker; RE-5205 Rotary Evaporator, Shanghai Yarong Biochemical Instrument Factory; KQ-300VDB Dual-Frequency CNC Ultrasonic Cleaner, Kunshan Ultrasonic Instrument Co., Ltd.; B-290 Spray Dryer, Buchi, Switzerland.

[0091] 3. Preparation method

[0092] 2400g of peony, 2400g of roasted licorice, made into 1000g granules.

[0093] Preparation process of formula granules of Shaoyao Gancao Decoction: decoct peony and licorice, filter the decoction; combine the filtrates, concentrate to a concentrated solution with a relative density of about 1.08-1.18 (60°C), spray dry, and make a dry extract powder. Add an appropriate amount of water, granulate, and sieve to obtain the formula granules of...

Embodiment 2

[0106] Embodiment 2 Thin-layer chromatography identification embodiment 1 is A in process condition 2 B 1 C 2 peony Herbal Licorice Decoction Formula Granules

[0107] 1. Identification of Radix Paeoniae Alba in Formula Granules of Shaoyao Gancao Decoction

[0108] 1.1 Reagents and Reagents

[0109] Radix Paeoniae Alba reference medicinal material: batch number 120905-200407, purchased from China Institute for the Control of Pharmaceutical and Biological Products;

[0110] Paeoniflorin reference substance: batch number 10736-200735, purchased from China Institute for the Control of Pharmaceutical and Biological Products;

[0111] Test product: batch numbers 20110914, 20120101, 20120102, 20120103, produced by Kangmei Pharmaceutical Research Institute according to the process conditions described in Example 1. 2 B 1 C 2 when the method is prepared;

[0112] Thin-layer board: Silicone G thin-layer board (Qingdao).

[0113] Reagents are analytically pure ...

Embodiment 3

[0160] Embodiment 3 detects that embodiment 1 is A at process condition 2 B 1 C 2 Shaoyao Gancao Decoction prepared in time Heavy metal content of square particles

[0161] For the detection items, refer to the Chinese Pharmacopoeia 2010 edition, one Huanglian Shangqing Pill [check] item, take about 1 g of the Shaoyao Gancao Decoction formula granules prepared in Example 1, accurately weigh it, and check the residue on ignition according to the Chinese Pharmacopoeia 2010 edition one Appendix IXJ) Burn until completely ashed. Take the remaining residue and check according to the second method (Appendix IX E of the Chinese Pharmacopoeia 2010 Edition), the results show that the weight percentage of heavy metals does not exceed 25ppm.

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Abstract

The invention provides a peony and liquorice soup formula granule, and a preparation method and a detection method of the peony and liquorice soup formula granule. The preparation method comprises the steps of weighing peony and liquorice at a mass ratio of 1:1, adding water for decocting and extracting, merging filtrate, decompressing and condensing the filtrate to obtain a concentrated solution, drying the concentrated spray, adding water for granulating and sieving, and obtaining the peony and liquorice soup formula granule. The detection method comprises the steps of identifying the peony and liquorice soup formula granule by a thin-layer chromatography, and measuring the heavy metal content, the organo-chlorine pesticide residual amount, the fingerprint spectrum, the extract content and the paeoniflorin content of the peony and liquorice soup formula granule. The peony and liquorice soup formula granule inherits advantages of a traditional Chinese medicine single-formula granule, fully considers interaction during decocting (or other processing) of a decoction piece, and has a higher value, and the detection method allows the quality of the peony and liquorice soup formula granule to be controlled more effectively, so that the peony and liquorice soup formula granule is safer to use.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine. The invention specifically relates to a formula granule and a preparation method and a detection method thereof, in particular to a Shaoyao Gancao decoction formula granule and a preparation method and a detection method thereof. Background technique [0002] Shaoyao Gancao Decoction was first recorded in "Treatise on Febrile Diseases". The original text is: If the Jue recovers and the foot is warm, give it Shaoyao Gancao Decoction, and the feet will stretch out. Composition: 4 liang each of peony and licorice (burnt), boil 1 liter of Wuhe with 3 liters of water, remove the water, divide the temperature and then serve. In the prescription, peony is sour and cold, licorice is sweet and warm for nourishing yin, nourishing blood, relieving emergency and tonifying deficiency. When the two are used together, the sour and sweet transform yin and relieve spasm. Indications for the deficienc...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/16A61P29/00A61P21/02A61P1/06A61P11/00G01N30/90G01N30/02G01N30/06
Inventor 叶秋菊马兴田许冬瑾向飞军吴小明陈有军
Owner KANGMEI PHARMA
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