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A glasses-wearing system for inducing myopia in rabbits and its application

A lens and mirror holder technology, which is applied in the headgear field of animal models of myopia, can solve the problems of small tissue volume, too steep cornea, and reduced experimental accuracy, and achieve the effect of light design, low cost, and convenient cleaning and care

Active Publication Date: 2015-12-30
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although guinea pigs and mice are easy to operate, their eyeballs are small and the cornea is too steep (guinea pig eyeball diameter is 10mm, mice are smaller and the proportion of intraocular tissue structure is quite different from that of humans), and it is impossible to observe the changes of some fine optical indicators such as Anterior chamber depth, lens thickness (the eyeball is too small, the amount of change is too small to exceed the detection limit of the instrument, it is not easy to detect the difference before and after induction), and the amount of tissue that can be obtained when detecting biochemical indicators such as proteins is very small, and several mice are needed Only when the experimental animals are combined can they be detected, and the accuracy of the experiment is reduced
The cost of experimenting with monkeys is relatively high, and it is difficult to carry out in general scientific research institutions
[0008] The diameters of rabbit eyeballs and corneas are similar to those of humans. If rabbits can be used as myopia models, more accurate optometry indicators such as corneal topography and wavefront aberration can be detected. Moreover, the amount of tissue provided by rabbit eyes is relatively rich, which is convenient Experimental detection, but currently there is no glasses-wearing system that can be used to induce myopia in rabbits, and it is impossible to construct an effective animal model of rabbit myopia

Method used

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  • A glasses-wearing system for inducing myopia in rabbits and its application
  • A glasses-wearing system for inducing myopia in rabbits and its application
  • A glasses-wearing system for inducing myopia in rabbits and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Such as figure 1 As shown, the glasses wearing system of the present invention includes: a truncated conical mask 1, a mirror holder 2, an induced lens 4, a fixing belt 7, and a buckle 8, wherein openings 6 and 5 are arranged at the front and back of the truncated conical mask, wherein the openings The circumference of 6 is 10cm, the middle part of the frustum-shaped mask is hollow, and there are 2 holes on the side of the frustum-shaped mask. The diameter of the hole is 4cm. The circular opening 6 provided makes it very convenient for the experimental animal to breathe and eat, so as to avoid affecting the growth and development of the experimental animal. The rear end is provided with a larger opening 5 so that the mask can be worn on the animal's head better. Described mirror holder 2 is circular truncated, is fixed on the circular truncated mask 1, and communicates with 2 holes on the truncated circular mask side, its bottom diameter of mirror holder 2 is 5cm, and t...

Embodiment 2

[0031] Such as figure 1 As shown, the glasses wearing system of the present invention includes: a truncated conical mask 1, a mirror holder 2, an induced lens 4, a fixing belt 7, and a buckle 8, wherein openings 6 and 5 are arranged at the front and back of the truncated conical mask, wherein the openings The circumference of 6 is 12cm, the middle part of the frustum-shaped mask is hollow, and there are 2 holes on the side of the frustum-shaped mask. The diameter of the hole is 5.3cm. The circular opening 6 provided at the front end makes it very convenient for the experimental animal to breathe and eat, so as to avoid affecting the growth and development of the experimental animal. The rear end is provided with a larger opening 5 so that the mask can be worn on the animal's head better. Described mirror holder 2 is conical shape, is fixed on the frustum-shaped mask 1, and is coaxial with 2 holes on the side of the truncated-conical mask, and its bottom diameter of mirror hold...

Embodiment 3

[0033] Such as figure 1 As shown, the glasses wearing system of the present invention includes: a truncated conical mask 1, a mirror holder 2, an induced lens 4, a fixing belt 7, and a buckle 8, wherein openings 6 and 5 are arranged at the front and back of the truncated conical mask, wherein the openings The circumference of 6 is 16cm, the middle part of the frustum-shaped mask is hollow, and there are 2 holes on the side of the frustum-shaped mask. The diameter of the hole is 6cm. The circular opening 6 provided makes it very convenient for the experimental animal to breathe and eat, so as to avoid affecting the growth and development of the experimental animal. The rear end is provided with a larger opening 5 so that the mask can be worn on the animal's head better. Described mirror holder 2 is circular truncated, is fixed on the truncated circular mask 1, and communicates with 2 holes on the circular truncated mask side, its bottom diameter of mirror holder 2 is 7cm, and t...

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Abstract

The invention discloses a glasses wearing system for inducing rabbit myopia and application thereof. The glasses wearing system comprises a cone-shaped face mask, lens supports, inducing lenses, fixing belts and buckles. The inducing lenses are convenient to disassemble, and different lenses can be replaced according to experimental requirements. According to the glasses wearing system, the movable buckles which are convenient to disassemble are adopted, so that the defect of inconvenience in disassembly existing in the prior art is overcome. The glasses wearing system also comprises an Elizabethan collar, which can effectively prevent an experimental animal from damaging an experimental head cover during scratching and guarantees the success rate of the experiment. The face mask is preferably made of a nylon material, and thus has extremely high plasticity and forms a natural barrier to prevent the animal from peeking and looking around. According to the glasses wearing system, only the hair around the eyes of the experimental animal is cut, so that no physiological injury is caused to the experimental animal and the survival rate of the animal is guaranteed. The glasses wearing system is suitable for the experimental animals such as rabbits, dogs and cats.

Description

technical field [0001] The invention relates to animal experiment equipment, in particular to a headgear for inducing myopia animal models such as rabbits, cats and dogs. Background technique [0002] The study of animal models of myopia has established two experimental models, namely: form deprivation myopia (FDM), which refers to the myopia caused by suturing eyelids, wearing translucent lenses or opaque hoods to affect the visual development of animals ; Lens induced myopia (LIM), or defocus myopia (defocus myopia), refers to the myopia caused by forcing the animal to see near or wearing a negative spherical lens to focus the image of the object behind the retina, thereby causing the eye axis to elongate . The current research has made it clear that FDM and LIM are two completely different types of myopia in nature. [0003] There are many methods of myopia induction commonly used in experimental animals, including eyelid suture, Goggle lens method, etc., but these meth...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01K29/00
Inventor 吴捷向琎琎
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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