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Soluble coaxial cone multilayer microneedle, microneedle array and preparation method thereof

A microneedle array, soluble technology, applied in other medical devices, drug devices, etc., can solve problems such as inability to realize drugs, and achieve the effect of preventing inactivation and avoiding mutual reactions

Active Publication Date: 2016-03-23
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Each layer of these multi-layer multi-drug microneedles is in contact with the intradermal environment, and the release of drugs is simultaneous, and it is impossible to achieve time-sharing, fixed-speed, and programmed release of different drugs.

Method used

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  • Soluble coaxial cone multilayer microneedle, microneedle array and preparation method thereof
  • Soluble coaxial cone multilayer microneedle, microneedle array and preparation method thereof
  • Soluble coaxial cone multilayer microneedle, microneedle array and preparation method thereof

Examples

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Effect test

preparation example Construction

[0046] The preparation method of the above-mentioned soluble coaxial cone multilayer microneedle array comprises the following steps:

[0047] (1) Using CNC micro-milling technology to prepare the central layer and the outer layer master mold, and then use PDMS to replicate the center layer and the outer layer. The shape of the center layer master mold is conical or conical cylindrical, and the outer layer master mold The shape of the mold is conical, and the material of the main mold is brass, aluminum or alloy;

[0048] (2) Using the central layer main mold and female mold obtained in step (1) to prepare the central layer of the soluble coaxial cone multilayer microneedles by one-step method or step-by-step method;

[0049] (3) Use the outer layer master mold and female mold obtained in step (1) to wrap one or more layers of The outer layer, that is, the soluble coaxial cone multilayer microneedles.

[0050] Using CNC micro-milling technology for precision structure moldin...

Embodiment 1

[0058] Mold fabrication: Fabricate a 10 × 10 rectangular microneedle array master mold using micromilling technology (see figure 1 ), master mode A (see Figure 12 ): The microneedles are conical, with a base diameter of 300 μm, a length of 800 μm, and an interaxial distance of 1 mm; master mold B (see Figure 13 ): The microneedles are conical, with a base diameter of 225 μm, a length of 600 μm, and an interaxial distance of 1 mm; master mold C (see Figure 14 ): Conical shape, bottom diameter 300μm, top diameter 225μm, length 200μm, axial distance 1mm. main form D (see Figure 15 ): The microneedle is conical cylindrical, the diameter of the bottom cylindrical part is 125 μm, the length is 400 μm, the diameter of the bottom of the top conical part is 125 μm, the length is 200 μm, and the distance between the axes is 1 mm. Replicate PDMS female molds a, b, c and d using the master mold (see Figure 16-19 ).

Embodiment 2

[0060] Methylene blue dyed soluble coaxial cone multilayer microneedles

[0061] In this embodiment, a dissolvable conical multi-layer microneedle array containing 100 microneedles, wherein the appearance of the microneedles is cone-shaped, the external dimensions are: the height is 800 μm, the diameter of the bottom surface is 300 μm, and its internal structure includes conical A central layer and an outer layer wrapped around the central layer.

[0062] The preparation method of the above-mentioned soluble coaxial cone multilayer microneedle array comprises the following steps:

[0063] (1) Dissolve 40 mg of Carbopol in 200 μL of deionized water under stirring at 800 rpm, adjust the pH to 6 with 10 M NaOH, and pour the formed uniform glue into the female mold b (see Figure 17 ), centrifuged at 4000rpm for 20min, dried in an oven at 45°C for 8 hours, and demolded to obtain a conical central layer 101 arranged on the base layer;

[0064] (2) Dissolve 1 mg of methylene blue ...

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Abstract

The invention discloses a soluble coaxial cone multi-layer microneedle. Its appearance is cone-shaped, and its internal structure includes a cone-shaped or cone-cylindrical central layer and one or more outer layers wrapped around the central layer. The central layer and the outer layer are both made of active drugs and / or structural materials, and the mass ratio of the active drugs and structural materials is 10:1 to 1:100. The multi-layer structure of the microneedle can be dissolved layer by layer during contact with body fluids in the skin, thereby achieving programmable control of the release time and amount of one or more drugs, and can be used locally on the skin. treatment or systemic administration.

Description

technical field [0001] The invention relates to biomedical preparations, in particular to a soluble coaxial cone multilayer microneedle and a preparation method thereof. Background technique [0002] Protein peptides and nucleic acid biomacromolecular drugs occupy an increasingly important position in the field of medicine and beauty, but due to stability factors, these drugs cannot be administered through the most basic oral route of administration. Drug administration is the most important and reliable route, but injection administration has its disadvantages in safety and compliance that are difficult to overcome. The convenient, reliable and highly compliant route of administration of biopharmaceuticals has become the focus of research in the field of pharmacy. [0003] As the most promising development direction of transdermal drug delivery, microneedle transdermal drug delivery combines the efficacy of injection drug delivery with the safety, convenience and high comp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0046
Inventor 吴传斌王清清
Owner SUN YAT SEN UNIV
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