Manufacturing method for personalized bracket for repairing of center plane across mandibular defect

Abstract

The invention discloses a manufacturing method for a personalized bracket for the repairing of a center plane across mandibular defect. The method comprising the following steps: designing a repairing model for a personalized profile and an internal microstructure of an individual defect through CT scanning in combination with a curved surface reperforating way; acquiring a repair body for the defect area through a cutting algorithm; manufacturing the repair body through BOOL arithmetic design via an EBSM method; implanting a three-dimensional reticular metallic support in the mandible defect area; fixing the repair body and two bone stumps through titanium bolts; adding ossifying material and autologous bone marrow stromal cells; and stitching soft tissues and conducting implant implanting after the completion of ossifying, so as to complete denture restoration. The method provided by the invention can better promote and guide the growth of the bones, has a good synosteosis effect for the implant and the around bones, and is suitable for long-term repairing.

Description

technical field [0001] The invention relates to a manufacturing method of a tissue engineering bracket for mandibular defect repair. Background technique [0002] In recent years, maxillofacial defects, especially mandibular defects, caused by tumors, infections, traffic accidents, etc., have been increasing year by year. In Europe alone, 1.5 million people need craniofacial surgery for bone repair every year, of which a considerable number One part is surgery on the mandible. [0003] The current mandibular defect repair surgery mainly adopts autologous bone grafting and metal plate prosthetic implantation. Vascularization surgery is very difficult, resulting in insufficient blood supply to the implant, which makes it difficult to control the absorption of the autologous bone implant and affects the repair effect. When the metal plate is implanted and repaired, although the personalized customization technology based on the patient's own bone structure is relatively matur...

AI Technical Summary

Problems solved by technology

However, the current tissue engineering repair based on stem cell technology uses absorbable materials as scaffold materials, which absorb quickly and cannot provide good mechanical support. It can only repair defects less than 3cm, and cannot repair more than 4 tooth positions (greater than 3cm). repair of defects, especially mandibular defects spanning the central plane

[0006] The difficulty in repairing mandibular defects lies in the restoration of the patient’s appearance and masticatory function. Therefore, tissue engineering technology has special requirements for the shape, material and structure of scaffolds and implants. Currently, it is used for mandibular defects with more than 4 teeth. There is no mature technology available in the field of repair of trauma-defective mandible above and the defect spans the central plane

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