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Method for extracting and purifying cacalia genus phenol

A technology of cranosol and a purification method, which is applied in the direction of organic chemistry, etc., can solve the problems disclosed and not yet seen in the industrial production process of cranosol, and achieve the effects of short time-consuming, short cycle and large sample loading

Inactive Publication Date: 2013-09-04
NANJING ZELANG MEDICAL TECH
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  • Abstract
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Problems solved by technology

[0005] In the prior art, there is no disclosure of the industrialized production process of cranosol

Method used

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  • Method for extracting and purifying cacalia genus phenol

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Embodiment 1

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Embodiment 3

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Abstract

The invention relates to a method for extracting and purifying cacalia genus phenol. The method for extracting and purifying cacalia genus phenol is characterized in that the overground part of cacalia genus phenol on Sakhalin is taken as a raw material, a methanol solution is added, ultrasonic extraction is carried out for 1-3 times in ultrasonic extraction equipment, an extracting solution is concentrated to recycle methyl alcohol, ethyl acetate is used for extracting to obtain an organic solvent layer, reduced pressure concentration is carried out, high pressure silica gel column chromatography is carried out, gradient elution is carried out by adopting petroleum ether and acetone, each elution part is collected, then thin layer chromatography is carried out, a component containing cacalia genus phenol is collected, is concentrated into extract and then is dissolved by methyl alcohol, purification is carried out by adopting preparative liquid chromatogram, eluting is carried out by adopting acetonitrile and water, a corresponding component is concentrated, and crystallization is carried out, thus the cacalia genus phenol is obtained. The method for extracting and purifying cacalia genus phenol is simple, preparative throughput is high, yield is high, product purity is good, and the method for extracting and purifying cacalia genus phenol is applicable to industrial production.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a method for extracting and purifying carcresol. Background technique [0002] Cacalonol, light yellow needle crystal, mp.207-208.5℃, molecular formula C 15 h 14 o 3 , molecular weight 242.27, structural formula is [0003] . [0004] Kamchaticol is a sesquiterpene compound derived from the aerial part of Cacalia auriculata DC.var.kamchatica (Maxim.) Matsumura, a plant of Compositae. Pharmacological studies have shown that cranosol has a sedative effect. In the pentobarbital test in mice, oral administration of this product at 50 mg / kg prolongs sleep by 160% (P<0.05). [0005] In the prior art, there is no disclosure of the industrialized production process of cranosol. Contents of the invention [0006] The present invention aims to overcome the above-mentioned technical defects and provide a method for extracting and purifying carracolol with goo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/92
Inventor 刘东锋万冬梅
Owner NANJING ZELANG MEDICAL TECH
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