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Marbofloxacin freeze-dried powder for injection and preparation method and application thereof

A technology of Mabaofloxacin and freeze-dried powder, which is applied in the field of Mabaofloxacin freeze-dried powder for injection and its preparation, to achieve the effects of convenient use, overcoming insolubility in water, and accurate dosage

Inactive Publication Date: 2013-09-04
ZHEJIANG HUAERCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0032] Currently there are tablet and injection formulations in foreign countries. We have developed Mabofloxacin for injection after research and development. The target animals are pet dogs and cats. , easy to use and other advantages, and overcome the characteristics of Mabaofloxacin insoluble in water, currently there is no marketed product of this dosage form

Method used

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  • Marbofloxacin freeze-dried powder for injection and preparation method and application thereof
  • Marbofloxacin freeze-dried powder for injection and preparation method and application thereof
  • Marbofloxacin freeze-dried powder for injection and preparation method and application thereof

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Embodiment 1

[0074] A freeze-dried powder of Mabaofloxacin for injection, consisting of the following components:

[0075] Mabaofloxacin: 250g; Zhejiang Guobang Pharmaceutical Co., Ltd., production batch number: 090705 Lactic acid (analytical pure): appropriate amount; Shanghai Yanchen Chemical Co., Ltd., batch number: 20100611 Activated carbon for injection: 4.8g; Shandong Xintong activated carbon filter material Co., Ltd. Lot number: 20100812

[0076] Add water for injection to: 5000ml;

[0077] Wherein, the addition amount of lactic acid is to adjust the pH of the preparation to be 4.8-4.9.

[0078] The preparation process of described marbofloxacin freeze-dried powder for injection comprises the following technical steps:

[0079] (1) Preparation of water for injection:

[0080] (a) Purified water is obtained by subjecting drinking water to reverse osmosis ion exchange;

[0081] (b) Purified water can be distilled to obtain water for injection;

[0082] (2) Sterilization of rubber...

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Abstract

The invention discloses marbofloxacin freeze-dried powder for injection and a preparation method and application thereof. The marbofloxacin freeze-dried powder consists of the following components: 250g of marbofloxacin, an appropriate amount of lactic acid, 4.8g of injectable activated carbon and the balance of water for injection, wherein the solution is 5000ml in total. The preparation process disclosed by the invention comprises the following steps of: (1) preparing the water for injection; (2) sterilizing rubber plugs; (3) purifying penicillin bottles; and (4) preparing the marbofloxacin freeze-dried powder. The marbofloxacin freeze-dried powder has the advantages of no influence by quality of water in application regions, accuracy in dosage, convenience for use and the like; and the defect that marbofloxacin is water-insoluble is overcome.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and more specifically relates to a freeze-dried powder of marbofloxacin for injection and a preparation method and application thereof. Background technique [0002] Marbofloxacin is another third-generation fluoroquinolone antibacterial after Enrofloxacin, Danofloxacin, Sarafloxacin and Difloxacin The drug was first developed by Roche in Switzerland, further developed by Vetoquinol and first launched in the UK in 1995, and then successively launched in France, the United States and Europe and listed as a special drug for animals. Currently approved for use in dogs, cats and cows. [0003] Mabaofloxacin has the characteristics of broad antibacterial spectrum, strong antibacterial activity, and long effective half-life. Its activity on aerobic bacteria is similar to or slightly stronger than ofloxacin, and it shows higher activity than ofloxacin on most anaerobic bacteria. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/5395A61P31/04
Inventor 孙国庆
Owner ZHEJIANG HUAERCHENG PHARMA
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