Metal microneedle array, transdermal drug delivery patch, microneedle roller and microneedle electrode array

A technology of microneedle array and electrode array, which is applied in the field of medical cosmetic equipment and medicine, can solve the problems of low flexibility in structural design, complex manufacturing process, and poor consistency, and achieve the effect of convenient and reliable measurement, beautiful appearance, and firm structure

Active Publication Date: 2015-09-30
SHANGHAI RUNTONG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, such as patents CN1562402A, US 20100130940-A1 and CN1415385A, which mainly manufacture microneedle arrays on the same metal substrate, but the manufacturing process is complicated, the cost is high, and the flexibility of structural design and application is low; on the other hand, For example, patents CN102727992A, CN102166387A, and CN101829396A are mainly microneedle arrays formed by arranging and assembling a single metal microneedle on a substrate of other materials according to a certain pitch, and there are also problems of complicated manufacturing process, high cost, and poor consistency. question

Method used

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  • Metal microneedle array, transdermal drug delivery patch, microneedle roller and microneedle electrode array
  • Metal microneedle array, transdermal drug delivery patch, microneedle roller and microneedle electrode array
  • Metal microneedle array, transdermal drug delivery patch, microneedle roller and microneedle electrode array

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Figure 1-Figure 17 The metal microneedle array provided by the present invention is shown, the metal microneedle array includes a substrate 1, and a metal sheet 2 fixed on the surface of the substrate 1, and / or one side edge is embedded in the The metal flakes 2 in the substrate 1, and / or at least two metal flakes 2 arranged at a certain distance and fixed on the surface of the substrate 1, and / or at least two metal flakes 2 arranged at a certain distance and one side edge embedded in the surface of the substrate 1 The metal foil 2 in the substrate 1, the metal foil 2 has an array of microneedles 3 protruding outward at least on one edge thereof, and the array of microneedles 3 includes at least two microneedles arranged at a certain interval 3. The microneedle 3 protrudes from the surface of the substrate and is perpendicular to it or at a set angle, and the microneedle 3 is perpendicular to or coplanar with the main plane where the central area of ​​the metal sheet 2...

Embodiment 2

[0058] An embodiment of the present invention provides a microneedle transdermal drug delivery patch based on the above-mentioned metal microneedle array, which consists of a metal microneedle array, a transdermal patch covering it, and a protective film or protective bag, wherein The transdermal patch contains one or more medicinal ingredients or cosmetic skin care products with therapeutic, health care or beauty care effects. Preferably, the transdermal patch is only covered on the protruding microneedles or needle tips in the metal microneedle array, which not only saves valuable pharmaceutical ingredients, but also easily controls the amount of medicine entering the skin. The grooves and holes on the microneedles can not only be used to store more drugs, and the administration time can be longer, but also can effectively avoid the problem of drugs falling out of the body during the process of piercing the skin. Various common physical or chemical methods such as dipping, c...

Embodiment 3

[0061] Figure 18 and Figure 19 A cross-sectional view of the structure of the microneedle transdermal drug delivery stamp or microneedle beauty stamp using the above-mentioned metal microneedle array provided by the present invention, the microneedle transdermal drug delivery stamp or microneedle beauty stamp includes a metal microneedle array, a base 9 and a protective cap 12, the metal microneedle array is permanently or detachably fixed on one end of the base 9, and the other end of the base 9 has a handle structure 10 that is convenient for manual operation, and the protective cap 12 can cover Protect the microneedles from damage on the base.

[0062] exist Figure 18 Among them, the metal microneedle array is fixed in the middle of one end of the base 9, and the surrounding base is provided with a raised structure 11 to limit the maximum penetration depth of the microneedles. The structure of the microneedles 3 is also different from the previous figures. Figure 19 ...

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Abstract

A metal microneedle array, a transdermal delivery patch with the metal microneedle array, and a microneedle transdermal delivery stamp. The metal microneedle array comprises a substrate (1) and at least one metal sheet (2). The substrate (1) is a solid plate, a solid cylindrical body or a hollow cylindrical body, and has an operation surface in a plane or curved surface shape. The metal sheet (2) is fixed on the substrate (1). Multiple integral microneedles (3) spaced to each other are formed on at least one edge of the metal sheet (2). Each microneedle (3) has a free end and a fixed end connected to the metal sheet (2). A structure of the free end of the microneedle (3) is a needle point (4). The metal sheet (2) is embedded in the operation surface, and at least one part of the microneedle (3) protrudes over the operation surface to form a preset angle with the operation surface. The microneedles (3) in the microneedle array have good consistency, and the manufacturing process of the microneedle array is simplified, and flexibility of the structure design and application is good.

Description

technical field [0001] The invention relates to the fields of medical cosmetic devices and medical technology, in particular to a metal microneedle array, a transdermal drug delivery patch, a transdermal drug delivery stamp and a microneedle electrode array based on the array. Background technique [0002] In recent years, microneedle transdermal drug delivery has attracted widespread attention. By pressing the microneedle array, it can instantly generate a large number of micron-sized pores in the stratum corneum and epidermis of the skin, so it can significantly improve the permeability of drugs. Theoretically, it should be applicable to any drug including biomacromolecular drugs without being restricted by molecular weight, drug polarity, melting point, etc., thus laying a solid foundation for the transdermal administration of these drugs. Before piercing the skin, if the surface of the microneedle array, especially the needle tip, has been covered with drugs, it can be c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00A61M35/00A61F13/02
CPCA61M2037/0023A61M2037/0046A61M37/0015
Inventor 岳瑞峰王燕
Owner SHANGHAI RUNTONG MEDICAL TECH CO LTD
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