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Method for extracting and purifying artemisinin

A purification method and artemisinin technology, applied in the direction of organic chemistry and the like, can solve the problems of low use amount of artemisinin solvent, complicated refining process, low purity, etc., and achieve less content of related substances, simple refining process, and simple activation method. Effect

Inactive Publication Date: 2013-08-14
SICHUAN YUTONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of artemisinin with high extraction efficiency, high content of artemisinin, low solvent usage, and beneficial to industrial application for the problems of low extraction rate, low purity and complicated subsequent refining process in the prior art. Artemisinin Extraction Method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The extraction and purification methods of artemisinin mainly consist of pulverizing Artemisia annua to obtain extracts, pastes, mixing materials, drying, column packing, column punching, elution, etc., as follows:

[0034] (1) Take 2,200 kg of Artemisia annua, crush it through a 10-mesh sieve, add 8 times the volume (L / kg) of No. 6 solvent oil, reflux at 55°C for 3.5 hours, concentrate the extract under normal pressure, and recover nearly 50%6 No. 1 solvent oil, after concentrating the water, concentrate under reduced pressure to reclaim No. 6 solvent oil, and collect the paste to obtain artemisinin extract;

[0035] (2) Put the extract into the paste pool and heat the paste below 70°C until the extract melts and is in a fluid state, it can be freely poured and fed; weigh the extract according to 110kg / column;

[0036] The activity of silica gel was measured by the method of testing the water absorption of silica gel, and the activity of silica gel was 1.5 / ml. Accordi...

Embodiment 2

[0046] The difference between this embodiment and embodiment 1 is only the difference of some parameters, and the extraction and purification method of artemisinin is as follows:

[0047] (1) Take 2,200 kg of Artemisia annua, crush it through a 20-mesh sieve, add 12 times the volume (L / kg) of No. 6 solvent oil, reflux at 50°C for 5 hours, concentrate the extract under normal pressure, and recover nearly 50%6 No. solvent oil, after concentration and water separation, concentrate under reduced pressure and reclaim No. 6 solvent oil, and collect the paste to obtain artemisinin extract;

[0048] (2) Put the extract into the paste pool and heat the paste below 70°C until the extract melts and is in a fluid state, it can be freely poured and fed; weigh the extract according to 110kg / column;

[0049] The silica gel activity was determined by the method of Example 1, and the silica gel activity was 1.5 g / ml. According to the amount of silica gel = the amount of extract 110㎏ × the act...

Embodiment 3

[0058] The difference between this embodiment and embodiment 1 and embodiment 2 is only the difference of some parameters, and the extraction and purification method of artemisinin is as follows:

[0059] (1) Take 2,200 kg of Artemisia annua, crush it through a 10-mesh sieve, add 10 times the volume (L / kg) of No. 6 solvent oil, reflux at 50°C for 3 hours, concentrate the extract under normal pressure, and recover nearly 50%6 No. solvent oil, after concentration and water separation, concentrate under reduced pressure and reclaim No. 6 solvent oil, and collect the paste to obtain artemisinin extract;

[0060] (2) Put the extract into the paste pool and heat the paste below 70°C until the extract melts and is in a fluid state, it can be freely poured and fed; weigh the extract according to 110kg / column;

[0061] The silica gel activity was determined by the method of Example 1, and the silica gel activity was 1.5 g / ml. According to the amount of silica gel = the amount of extra...

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Abstract

The invention discloses a method for extracting and purifying artemisinin. The method comprises the following steps of: (1) crushing artemisia apiacea and preparing artemisinin extractum; (2) melting the extractum: mixing the extractum and silica gel and drying to obtain material mixed silica gel; (3) performing wet column packing to obtain a silica gel column; (4) flatly paving the material mixed silica gel obtained in the step (2) on the silica gel column obtained in the step (3), standing, flushing the column and eluting; (5) collecting the eluent, concentrating, placing for 24 hours, crystallizing and centrifuging to obtain an artemisinin coarse product; and (6) refining the artemisinin coarse product obtained in the step (5). By adopting the method, the extraction efficiency is high, the artemisinin content is high, the using amount of solvents is small, and the method is favorable for industrial application.

Description

technical field [0001] The invention relates to the field of extracting traditional Chinese medicines, in particular to a method for extracting and purifying artemisinin. Background technique [0002] Artemisinin (Artemesinin) is a colorless needle-like crystal extracted from the Compositae plant Artemisia annua L., with the molecular formula C 15 h 22 o 5 . Artemisinin has special effects on falciparum malaria and cerebral malaria against chloroquine, and has the characteristics of high efficiency and low toxicity. [0003] The preparation method of artemisinin mainly includes chemical synthesis, biosynthesis, synthesis of artemisinin by plant tissue culture and extraction of artemisinin from Artemisia annua plants. At present, natural extraction is still the most widely used preparation method of artemisinin. Natural extraction methods mainly include organic solvent extraction, supercritical CO2 extraction, microwave extraction and other methods. [0004] The tradit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/20
Inventor 林明刚
Owner SICHUAN YUTONG BIOTECH
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