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Adenoviral assembly method

A technology of adenovirus and recombinant adenovirus, which is applied in the field of adenovirus assembly, can solve the problems such as the lack of extensive research or utilization of unique properties, lack of modification, etc.

Active Publication Date: 2013-08-07
SALK INST FOR BIOLOGICAL STUDIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These unique properties of them have not been widely studied or exploited due to the lack of tools needed to modify their genomes

Method used

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[0059] definition

[0060] "Nucleic acid" refers to deoxyribonucleotides or ribonucleotides and polymers thereof in single- or double-stranded form, as well as their complementary strands. The term encompasses nucleic acids that contain known nucleotide analogs or backbones with modified residues or linkages; that are synthetic, naturally occurring and non-naturally occurring; that are associated with A reference nucleic acid has similar binding properties and is metabolized similarly to a reference nucleotide. Examples of such analogs include, but are not limited to, phosphorothioates, phosphoroamidates, methylphosphonates, chiral-methylphosphonates, 2-O-methyl ribonucleotides, peptide nucleic acids (PNAs) .

[0061] Unless otherwise indicated, a particular nucleic acid sequence also implies conservatively modified variants thereof (eg, degenerate codon substitutions) and complementary sequences, as well as the sequence explicitly indicated. In particular, degenerate cod...

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Abstract

Methods of assembling modified adenoviruses, libraries of adenoviral gene modules and compositions thereof are provided herein.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application 61 / 374,198, filed August 16, 2010, which is hereby incorporated in its entirety for all purposes. Background of the invention [0003] There are 52 human adenoviruses that infect different human tissues, and hundreds more capable of infecting other species ranging from fish to primates. These viruses are highly efficient nanoscale machines capable of payloading their genetic material into the nucleus within 1 hour of infection. These DNA viruses do not integrate into host DNA, can be produced in high titers using well-established GMP protocols, and have been shown to be safe in research and human gene therapy applications for expression of abnormal genes. However, their potential applications have so far been limited by the fact that use has been almost exclusively limited to one variant, Ad5 or Ad2 / 5 chimeras, and by the inability to rapidly and systemat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/861C12N15/33C12N7/01
CPCC12N7/02C12N2710/10351C12N7/00C12N15/861C12N15/86C12N2710/10051C12N2710/10043C12N2800/70C12N2800/30
Inventor C.奥谢C.鲍尔斯
Owner SALK INST FOR BIOLOGICAL STUDIES
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