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Monascus ruber for high generation of lovastatin and gamma-aminobutyric acid and low generation of pigment, use thereof, and functional Monascus sp. prepared through using Monascus ruber

A technology of lovastatin and Monascus, which is applied in food preparation, microbial-based methods, applications, etc., can solve the problems of undiscovered patent publications, etc., and achieve the goals of inhibiting tumor cell proliferation, reducing blood fat and sleep, and improving sleep Effect

Inactive Publication Date: 2013-07-31
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Through the search, no published patent publications related to the patent application of the present invention have been found

Method used

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  • Monascus ruber for high generation of lovastatin and gamma-aminobutyric acid and low generation of pigment, use thereof, and functional Monascus sp. prepared through using Monascus ruber
  • Monascus ruber for high generation of lovastatin and gamma-aminobutyric acid and low generation of pigment, use thereof, and functional Monascus sp. prepared through using Monascus ruber
  • Monascus ruber for high generation of lovastatin and gamma-aminobutyric acid and low generation of pigment, use thereof, and functional Monascus sp. prepared through using Monascus ruber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Seed liquid medium (g / L): glucose 30-60g, peptone 10-20g, NaNO 3 5-10g, MgSO4 7H 2 O 1-5g, KH 2 PO 4 1-10g, inoculated with Monascus CGMCC NO.6860, cultured at 180rpm, 37°C for 12 hours to obtain seed solution.

[0045] Solid fermentation medium: Soak rice and water overnight at a mass volume ratio of 1:1~3, and sterilize at 121°C for 20 minutes.

[0046] Preparation of red yeast rice by solid-state fermentation: The thickness of the solid fermentation medium is 2-5cm. After the material is cooled, the prepared seed liquid is mixed into the solid fermentation medium according to the inoculum amount of 10%, cultivated at 37°C for 3-5 days, and transferred to 20~ Cultivate at 27°C for 2-4 weeks, with a humidity of 50-80%. After the fermentation, dry at 70°C to obtain functional red yeast rice.

[0047] Determination of Monacolink k content in functional red yeast rice prepared by Monascus CGMCC NO.6860:

[0048] HPLC conditions are: Agilent TC-18 (250mm × 4.6mm, 5...

Embodiment 2

[0059] Seed liquid medium (g / L): glucose 30-60g, peptone 10-20g, NaNO 3 5-10g, MgSO4 7H 2 O 1-5g, KH 2 PO 4 1-10g, inoculated with Monascus CGMCC NO.6860, cultured at 140-180rpm, 37°C for 24 hours to obtain seed liquid.

[0060] Solid fermentation medium: Soak oats and wheat bran / water at a ratio of 2-4:1 / 2-10 in mass volume overnight, and sterilize at 121°C for 20 minutes.

[0061] Preparation of red yeast rice by solid-state fermentation: The thickness of the solid fermentation medium is 3-6cm. After the material is cooled, the prepared seed liquid is mixed into the solid fermentation medium according to the inoculation amount of 15%. Culture at 37°C for 1-3 days, transfer to 20-27°C for 2-4 weeks, humidity 40-60%. After the fermentation is finished, dry at 70°C to obtain the functional red yeast rice of the present invention.

[0062] The method of the functional red yeast rice prepared by Monascus CGMCC NO.6860 is the same as that in Example 1.

[0063] The index m...

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Abstract

The invention relates to a Monascus ruber for the high generation of lovastatin and gamma-aminobutyric acid and the low generation of a pigment. The Monascus ruber is named as C002, belongs to Monascus sp., has a preservation number of CGMCC NO.6860, is preserved at China General Microbiological Culture Collection Center in Institute of Microbiology, Chinese Academy of Sciences on Datun Road, Chaoyang District of Beijing on November 26, 2012. The Monascus ruber has the advantages of high generation of lovastatin and gamma-aminobutyric acid, no generation or extremely-low generation of citrinin, no bitterness, and low generation of a Monascus pigment. Strains of the Monascus ruber CGMCC NO.6860 can utilize a plurality of culture mediums comprising rice, coarse rice, corn, cassava and the like to produce functional red yeast rice; and the Monascus ruber is especially suitable for the exploitation of relevant functional beverage products because of the Monascus pigment low-generation characteristic.

Description

technical field [0001] The invention belongs to the field of food biotechnology, and relates to monascus, in particular to a monascus with high lovastatin and gamma-aminobutyric acid production and low pigment production, its application and functional red yeast prepared by the monascus. Background technique [0002] In the search for effective blood lipid-lowering drugs, Japanese scholar Akira Endo and American scholar Albert discovered cholesterol synthesis inhibitors in Monascus ruber and Aspergillus terreus in 1979 and 1980, respectively. It is named Monacolin K (Monacolink) and Mivinolin respectively. Monacolin K and Mivinolin are the same type of active substances with the same structure, and the two substances were later collectively named lovastatin internationally. In 1985, Professor Akira Endo and others isolated other active ingredients similar in structure to Monacolin K: Monacolin L, MonacolinX, Monacolin M, Dihydromevinolin and Dihydromonacolin L from M. Mona...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/14A23L1/30A23L2/52A61K36/06A61P35/00C12R1/645
Inventor 陈勉华吉达维王玉荣孙妮娜高红王昌禄
Owner TIANJIN UNIV OF SCI & TECH
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