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System and method for manipulating and screening particles based on structural acoustic field

A technology of structural sound field and particles, applied in the direction of individual particle analysis, particle and sedimentation analysis, particle size analysis, etc., can solve the problem of batch processing of micro-nano particles, etc., and is not easy to be disturbed by external factors, has repeatability, and high reliability. Effect

Active Publication Date: 2015-08-12
深圳中科乐普医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing technology either processes individual particles or particles flowing through the sound field separately. This sorting method determines that this screening technology cannot process micro-nano particles in batches and cannot process batches of particles in parallel.

Method used

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  • System and method for manipulating and screening particles based on structural acoustic field
  • System and method for manipulating and screening particles based on structural acoustic field
  • System and method for manipulating and screening particles based on structural acoustic field

Examples

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Embodiment 1

[0036] Such as Figure 1 to Figure 3 As shown, one embodiment of the system for manipulating and screening particles based on the structural acoustic field of the present application includes a sample table, an ultrasonic emitting device and an artificial structure. The sample table is used to hold particles to be screened, and the ultrasonic emitting device is used to emit ultrasonic waves. , the artificial structure is a periodic structure, which is used to modulate the sound field to generate stronger acoustic radiation force, and to screen the particles to be screened.

[0037] In one embodiment, the sample stage is a sound-transmitting phantom made of gel, and its height can be set as required. In this specific embodiment, the height of the sample stage is 4 cm.

[0038] In one embodiment, the ultrasonic transmitting device includes a signal generator, a power amplifier and an ultrasonic transducer, the signal generator is used to generate a transmitting signal, and the ...

Embodiment approach

[0045] Such as Figure 4 As shown, the method for manipulating and screening particles based on the structure acoustic field of the present application, an embodiment thereof, comprises the following steps:

[0046] Step 402: Place the particles to be screened on the sample table, and set the artificial structure above the sample table; in this embodiment, the particles to be screened can be selected from tiny glass balls, specifically pickling beads produced by Sigma-Aldrich. The glass microspheres G4649-100G, G1145-100G and G8772-100G. The diameters of these three glass microspheres are <106 μm, 150-212 μm and 425-600 μm, respectively.

[0047] Step 404: the ultrasonic emitting device emits ultrasonic waves;

[0048] Step 406: The artificial structure regulates the sound field;

[0049] Step 408: The artificial structure screens the particles to be screened based on the acoustic radiation force generated by the modulation. The artificial structure can adsorb the screened...

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Abstract

A system for particle manipulation and sorting based on structural acoustic field comprises a sample holder, an ultrasound transmission device and an artificial structure, the sample holder is used to place particles to be sorted, the ultrasound transmission device is used to transmit ultrasound wave, the artificial structure is periodic structure used to modulate acoustic field to produce stronger acoustic radiation force and sort the particles to be sorted. And there is a method for particle manipulation and sorting based on structural acoustic field. Due to the sample holder, the ultrasound transmission device and the artificial structure, plurality of particles could be placed on the sample holder simultaneously, the artificial structure is used to modulate the acoustic field to produce stronger acoustic radiation force, trapping the specific particles under the lower surface of the artificial structure at the same time, realizing rapid, batch sorting and increasing the efficiency.

Description

technical field [0001] The present application relates to acoustic wave manipulation technology, in particular to a system and method for manipulating and screening particles based on a structural acoustic field. Background technique [0002] The research and development of micro-manipulation technologies for single atoms or macroscopic substances have had a major impact on biology, quantum optics, soft matter physics, biophysics and clinical medicine. Micro-manipulation technology not only provides an important research method for studying the basic mechanical, physical and biochemical properties of tiny particles such as metals, cells, and DNA, but also provides a necessary tool for the development of new biochemical analysis instruments for the screening of biological particles such as cells and platelets. technical support. The development of accurate, reliable, and low-cost control devices for tiny particles has become one of the frontier directions that has attracted ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B07C5/34G01N15/02G01N15/10
CPCB07C2501/0027B07C5/34
Inventor 郑海荣蔡飞燕李飞孟龙王辰
Owner 深圳中科乐普医疗技术有限公司
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