Liposome Extrusion Filtration Device

Abstract

The invention provides a lipidosome extruding and filtering device which comprises a material discharge pipe, an upper cover, an extruding outer seal gasket, a support plate, a filtering plate, a filtering membrane, an extruding inner seal gasket, a connector, a hoop and a hoop locking bolt; the center of the connector is provided with a material charge through hole; the center of the upper cover is provided a material discharge through hole of which the opening at the upper end is connected with the material discharge pipe; the bottom surface of the upper cover is provided with an annular seal groove and an internally sinking cylindrical groove; the support plate, the filtering plate, the filtering membrane and the extruding inner seal gasket are sequentially arranged in the cylindrical groove from inward to outward; the extruding outer seal gasket is arranged in the annular seal groove; the upper cover and the connector are fixed together through the hoop and the hoop locking bolt. According to the invention, nanocrystallized equipment and homogenized equipment are designed integrally; material particle size can be controlled accurately through replacing different filtering membranes; cross contamination is prevented; and the lipidosome extruding and filtering device is convenient to use, and can be widely applied to the nano medicament field.

Description

technical field [0001] The invention relates to a high-pressure filter device, in particular to a liposome extrusion filter device. Background technique [0002] When amphiphilic molecules such as phospholipids and sphingolipids are dispersed in the aqueous phase, the hydrophobic tails of the molecules tend to gather together and avoid the aqueous phase, while the hydrophilic heads are exposed to the aqueous phase, forming closed vesicles with a bilayer structure , called liposomes, ranging from 25 to 1000 nm in diameter. Liposome is a targeted drug carrier, which belongs to a new dosage form of targeted drug delivery system. It can embed drug powder or solution in nanometer-sized particles, which have a cell-like structure, enter the human body and be swallowed by the reticuloendothelial system to activate the body's autoimmune function and change the encapsulated drug The distribution in the body makes the drug mainly accumulate in tissues and organs such as liver, splee...

AI Technical Summary

Problems solved by technology

[0004] The existing high-pressure homogenizer and extrusion filter are separated, which will cause cross-contamination, and troublesome operation and maintenance

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