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Multifunctional anticancer nanometer medicine carrying controlled-release vesicle and preparation process thereof

A technology of nano-drug loading and preparation process, which is applied in the field of medicine, can solve the problems of patients' pain, and achieve the effects of easy operation, enhanced tolerance, and simple preparation process

Inactive Publication Date: 2013-07-03
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Radiotherapy and conventional chemotherapy are widely used clinically in the current tumor treatment. These two methods are mostly non-selective treatments. While killing tumor cells, they also kill a large number of normal cells in the human body, which has brought great harm to patients. Uncertainty about pain and treatment

Method used

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  • Multifunctional anticancer nanometer medicine carrying controlled-release vesicle and preparation process thereof
  • Multifunctional anticancer nanometer medicine carrying controlled-release vesicle and preparation process thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] A preparation process of multifunctional anti-cancer nano drug-loaded controlled-release vesicles, comprising the following steps:

[0046] Step 1: Dissolve tetra-p-hydroxyphenylporphyrin in ethanol for later use, and the concentration of the solution is 0.8mmol / L.

[0047] Step 2: Take 7.5mL of 0.5M CTAB solution, add 250μL of 0.1M chloroauric acid and 1.65mL of water in turn, stir well and quickly add 600μL of 10mM NaBH 4 Solution, ice bath, magnetic stirring for 3 minutes, then 30 ° C constant temperature exposure for 2 hours to obtain gold species, ready to use.

[0048] Step 3: Take 10mL 0.5M CTAB solution, add 500μL 0.1M chloroauric acid, 50μL 10mM AgNO 3 solution, 55 μL of 0.2M ascorbic acid, and 12 μL of the gold species prepared in step 2, stirred for 2-3 minutes, and kept at 30° C. for 12 hours to obtain gold rods.

[0049] Step 4: Take the gold rod prepared in step 3, centrifuge and wash it twice with pure water, and set aside.

[0050] Step 5: Add 0.2 mg ...

Embodiment 2

[0053]A preparation process of multifunctional anti-cancer nano drug-loaded controlled-release vesicles, comprising the following steps:

[0054] Step 1: Dissolve tetraphenylporphyrin in ethanol for later use, and the concentration of the solution is 1 mmol / L.

[0055] Step 2: Take 7.5mL 0.5M CTAB solution, add 250μL 0.1M chloroauric acid, 1.65mL water in sequence, stir well and then quickly add 600μL 12mM NaBH 4 Solution, ice bath, magnetic stirring for 3 minutes, then 30 ° C constant temperature exposure for 2 hours to obtain gold species, ready to use.

[0056] Step 3: Gold rod preparation, take 10mL 0.5M CTAB solution, add 500μL 0.1M chloroauric acid, 70μL 10mM AgNO 3 Solution, 55 μL of 0.2M ascorbic acid, 12 μL of the gold seeds prepared in step 2, after adding the gold seeds, stir for 2-3 minutes, and keep the temperature at 30°C for 12 hours to get the gold rods.

[0057] Step 4: Take the gold rod prepared in step 3, centrifuge and wash it twice with pure water, and s...

Embodiment 3

[0061] A preparation process of multifunctional anti-cancer nano drug-loaded controlled-release vesicles, comprising the following steps:

[0062] Step 1: Dissolve tetrakis(4-carboxyphenyl)porphyrin in ethanol for later use, the solution concentration is 0.3mmol / L.

[0063] Step 2: Take 6mL of 0.1M CTAB solution, add 100μL of 0.1M chloroauric acid, 1mL of water in turn, stir well and quickly add 550μL of 10mM NaBH 4 Solution, ice bath, magnetic stirring for 3 minutes, and then 30 ° C constant temperature exposure for 5 hours to obtain gold species, ready to use.

[0064] Step 3: Take 10mL 0.1M CTAB solution, add 400μL 0.1M chloroauric acid, 30μL 8mM AgNO 3 Solution, 40 μL of 0.1M ascorbic acid, 8 μL of the gold seeds prepared in step 2, after adding the gold seeds, stir for 2-3 minutes, and keep the temperature at 30°C for 9 hours to get the gold rods.

[0065] Step 4: Take the gold rod prepared in step 3, centrifuge and wash it twice with pure water, and set aside.

[0066...

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Abstract

The invention discloses a multifunctional anticancer nanometer medicine carrying controlled-release vesicle which structurally comprises an outer shell, an inner core and a sandwich layer, wherein the outer shell of the vesicle is formed by the self-aggregation bi-molecule layer of reagent A; the inner core is photo-thermal therapy reagent B, capable of adjusting and controlling light absorption wavelength coverage and is buried in the cavity of the multifunctional anticancer nanometer medicine carrying controlled-release vesicle; active chemotherapy anti-cancer molecular reagent C is filled in the crack between the outer shell and the inner core; the reagent A is PDT (Photodynamic Therapy) anticancer material; the reagent B is PET (photo-thermal therapy) anticancer material; and the reagent C is chemotherapy anti-cancer material. The invention firstly effectively composites medicine carrying controlled release, PDT and PET in the nanometer vesicle, realizes multiple functions, and overcomes the defect of single function in the prior art, thereby improving the tolerance of patients in anticancer treatment and effectiveness and durability in anti-tumor treatment and being simple in preparation process and easy in operation.

Description

Technical field [0001] The present invention involves a composite anti -cancer function nano -load control and its preparation, which is a pharmaceutical field. Background technique [0002] Tumor is a major illness that seriously threatens human health today.The current tumor therapy is widely used in radiotherapy and routine chemotherapy in clinical treatment. Most of these two methods are non -selective treatment. While killing tumor cells, they also killed a large number of normal cells.Pain and uncertainty of treatment.The poisonous and side effects of conventional treatment for the normal tissue organs of the human body have caused patients to reduce the efficacy from physiological to their hearts. Therefore, anticancer drugs have gradually shifted to targeted selective research and long -term slow -release agents. [0003] Drugs currently used for tumor -targeted therapy include lipoplastin, molecular targeting drugs, and drug slow release agents. [0004] Nano drugs can i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/704A61K9/127A61P35/00
Inventor 卢小泉杨建明王志华唐智勇
Owner NORTHWEST NORMAL UNIVERSITY
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