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Preparation method of high-strength nano-composite hydrogel with rapid dual responses of pH and temperature

A nano-composite, high-strength technology, applied in the field of nano-composite hydrogel preparation, can solve the problems of poor mechanical properties of hydrogel products and no value of drug sustained release, etc., and achieve the effect of rapid deswellability

Inactive Publication Date: 2013-06-12
HUNAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patents CN101215350A, CN101319019A and CN101161689 B also disclose the preparation of nanocomposite temperature-sensitive hydrogels using modified inorganic nanoclays (such as sodium pyrophosphate-modified lethonite, hectorite) as physical crosslinking agents, but do not involve pH Responsive and dual-responsive hydrogels
[0011]And DMAEMA is also widely used in the synthesis of multi-response gels. The synthesis method includes the use of chemical cross-linking agent BIS for cross-linking, and the use of ultraviolet cross-linking for polymerization etc., but the mechanical properties of these hydrogel products are still very poor, and the lowest critical transition temperature LCST temperature is higher than 40 ° C, this temperature is higher than the body temperature and does not have the value of being applied to drug sustained release

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Prepare the pre-solution: dissolve 4g of monomer, 0.52g of lithium diatomaceous earth, 0.08g of BIS, 0.04g of sodium pyrophosphate in 24ml of water and put it in a transparent flask, and stir it in an ice bath at 0°C under nitrogen protection for 60 Minutes until uniform and transparent, then add 0.48g of nanocellulose whiskers and stir for 30 minutes, then ultrasonically oscillate for 10 minutes until uniform, wrap the flask with black cloth until it is opaque, add 0.02g of photocatalyst diketoglutaric acid, and place in an ice bath After stirring for 10 minutes, transfer to a test tube and seal;

[0043] (2) Place the sealed test tube containing the above pre-polymerization solution in front of a 360nm wavelength ultraviolet light source, the distance between the test tube and the light source is 10cm, and the pre-polymerization solution is irradiated under ultraviolet light for 30 minutes;

[0044] (3) Take out the container in (2) and react at -18°C for 24 hours...

Embodiment 2

[0049] (1) Prepare the pre-solution: Dissolve 4.4g monomer, 0.87g lepidolite, 0.066g BIS, 0.067g sodium pyrophosphate in 24ml water and place in a transparent flask, stir in an ice bath at 0°C under nitrogen protection After 60 minutes until uniform and transparent, add 0.96g of nanocellulose whiskers and stir for 30 minutes, then ultrasonically oscillate for 10 minutes until uniform, wrap the flask with a black cloth until it is opaque, add 0.022g of photocatalyst diketoglutaric acid, and place in an ice bath Stir in medium for 10 minutes and transfer to test tube to seal;

[0050] (2) Place the sealed test tube containing the above pre-polymerization solution in front of a 360nm wavelength ultraviolet light source, the distance between the test tube and the light source is 10cm, and the pre-polymerization solution is irradiated under ultraviolet light for 30 minutes;

[0051] (3) Take out the container in (2) and react at -18°C for 24 hours;

[0052] (4) After the obtained ...

Embodiment 3

[0056] (1) Prepare the pre-solution: Dissolve 4.2g monomer, 1.31g lepidolite, 0.04g BIS, 0.1g sodium pyrophosphate in 24ml water and place in a transparent flask, stir in an ice bath at 0°C under nitrogen protection After 60 minutes until uniform and transparent, add 1.1g of nanocellulose whiskers and stir for 30 minutes, then ultrasonically oscillate for 15 minutes until uniform, wrap the flask with a black cloth until it is opaque, add 0.04g of photocatalyst diketoglutaric acid, and place in an ice bath Stir in medium for 10 minutes and transfer to test tube to seal;

[0057] (2) Place the sealed test tube containing the above pre-polymerization solution in front of a 360nm wavelength ultraviolet light source, the distance between the test tube and the light source is 10cm, and the pre-polymerization solution is irradiated under ultraviolet light for 30 minutes;

[0058] (3) Take out the container in (2) and react at -18°C for 24 hours;

[0059] (4) After the obtained gel w...

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PUM

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Abstract

The invention relates to a preparation method of high-strength nano-composite hydrogel capable of rapidly responding to pH and temperature. The preparation method taking dimethylaminoethyl methacrylate as a monomer, inorganic nanometer clay and N,N'-methylenebisacrylamide as co-crosslinking agents, and a nanometer cellulose whisker as a gel composite reinforcer comprises the following steps of: stirring the components, carrying out uniform ultrasonic oscillation, carrying out photo-initiation free radical polymerization in 0 DEG C ice-bath, then reacting at -18 DEG C for 24 hours to obtain the final gel product. The hydrogel prepared by the method has the dual responses of temperature and pH and excellent mechanical performance and can rapidly swell and deswell; and the lowest transformation temperature of the hydrogel is close to temperature of human bodies; raw materials are cheap; the preparation method is simple; and the high-strength nano-composite hydrogel has the potential of application in fields such as sustained release of medicines and tissue engineering.

Description

technical field [0001] The invention belongs to a method for preparing a hydrogel, in particular to a method for preparing a nanocomposite hydrogel with high mechanical strength, which can produce rapid response to changes in ambient temperature and pH value, thereby producing volume transformation. [0002] Background technique [0003] Polymer gel refers to a system composed of a three-dimensional network structure of polymer compounds and a solvent, in which the polymers are connected by van der Waals force, chemical bond force, physical winding force, hydrogen bond force, etc. Since it is a three-dimensional network structure, it cannot be dissolved by solvents, and at the same time, it can be dispersed in solvents and can maintain a certain shape. Although the solvent cannot dissolve the polymer with a three-dimensional network structure, the solvophilic group in the polymer compound can be affected by the solvent to swell the polymer, which is also the reason for the ...

Claims

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Application Information

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IPC IPC(8): C08F220/34C08F2/48C08F2/44C08K9/02C08K3/34C08K3/32
Inventor 陈一
Owner HUNAN UNIV OF TECH
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