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Segmented copolymer capable of being self-assembled into micelle and preparation method thereof

A self-assembly and copolymer technology, applied in the field of amphiphilic block copolymers and their preparation, can solve the problems of less applicable monomers and harsh reaction conditions, and achieve mild reaction conditions, high product purity, and good controllability. Effect

Active Publication Date: 2013-05-22
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the above-mentioned synthesis method has disadvantages such as relatively harsh reaction conditions and less applicable monomers.

Method used

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  • Segmented copolymer capable of being self-assembled into micelle and preparation method thereof
  • Segmented copolymer capable of being self-assembled into micelle and preparation method thereof
  • Segmented copolymer capable of being self-assembled into micelle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1) Prepare BMA:CPAD:AIBN=60:1:0.1 toluene solution system according to the molar ratio. Quenched for 2 min to stop the reaction. Diluted with a small amount of toluene, precipitated with methanol, filtered and dried to obtain a red solid, namely polybutyl methacrylate (PBMA);

[0030] 2) According to the molar ratio DMA:PBMA:AIBN=350:1:0.1, add the metered DMA, PBMA and AIBN into the reaction solution, seal it and freeze and degas it three times, react in an oil bath at 65°C for 13h, liquid nitrogen Quenched for 2 min to stop the reaction. Diluted by adding a small amount of toluene, precipitated with methanol, filtered and dried to obtain a pink solid, namely poly(butyl methacrylate-dimethylaminoethyl methacrylate), relative 1 HNMR spectrum as figure 1 shown;

[0031] 3) Prepare the obtained poly(butyl methacrylate-dimethylaminoethyl methacrylate) solid into a 0.1 mg / mL tetrahydrofuran solution, add deionized water drop by drop, and wait for the solvent to evaporat...

Embodiment 2

[0033] Similar to Example 1, the difference lies in the BMA: CPAD: AIBN=120: 1: 0.1 toluene solution system in step 1), and the rest are the same as in Example 1 to obtain poly(butyl methacrylate-dimethylaminoethyl methacrylate) ) block copolymer, the prepared amphiphilic block copolymer forms a micellar solution in deionized water (such as Figure 2b shown).

Embodiment 3

[0035] Similar to Example 1, the difference is that the reaction time described in step 2) is 6h, and the rest are the same as Example 1 to obtain a poly(butyl methacrylate-dimethylaminoethyl methacrylate) block copolymer, and the prepared The resulting amphiphilic block copolymers formed micellar solutions in deionized water (e.g. Figure 2c shown).

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Abstract

The invention discloses an amphipathic segmented copolymer capable of being self-assembled into micelle. The segmented copolymer is formed by taking poly-n-butyl methacrylate as a first block and taking PDMAEMA as a second block, namely, poly (butyl methacrylate-PDMAEMA) is prepared by a reversible addition-fragmentation chain transfer polymerization (RAFT) method. According to the segmented copolymer, the block length ratio can be adjusted in a planned mode by adjusting the molar ratio of butyl methacrylate to a PDMAEMA monomer to a chain transfer agent, and the amphipathic segmented copolymer is high in controllability, mild in reaction conditions and high in product purity. The segmented copolymer solution is subjected to microphase separation in a selective solvent, and a self-assembled micelle structure which has nanometer size, narrow distribution and protophobic solvent core and solvent shell is spontaneously formed. The segmented copolymer can be used for research in the field of biological medicines in a nano controlled release system.

Description

technical field [0001] The invention relates to a block copolymer, in particular to an amphiphilic block copolymer capable of self-assembling into micelles and a preparation method thereof. Background technique [0002] Amphiphilic block copolymers spontaneously form a nanoscale, narrowly distributed, self-assembled, solvophobic core and solvation shell due to microphase separation of the hydrophilic and hydrophobic blocks in a selective solvent structure, called a polymeric micelle. Compared to small molecule micelles such as surfactant micelles, polymeric micelles have a lower critical micelle concentration and, due to the less mobility of their segments, have a lower rate of disassociation. In recent years, the research of polymer micelles controlled release drug delivery system applied in the field of medicine has been very active. Polymer micelles are used in controlled-release drug delivery systems, that is, drugs are located inside micelles through dissolution and e...

Claims

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Application Information

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IPC IPC(8): C08F293/00C08F220/18C08F220/34C08F4/04
Inventor 戴李宗宋存峰程玲余世荣叶华立毛杰陈国荣李聪罗伟昂
Owner XIAMEN UNIV
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