Peptide fragment-containing cyanoacrylate derivative as well as preparation method and use thereof

Abstract

The invention relates to a peptide fragment-containing cyanoacrylate derivative, wherein the structure of the derivative is shown by a formula I, a formula II and a formula III, respectively. The ethylenic bond in the derivative can be initiated by anions to quickly carry out intermolecular polymerization and generate adhesive-glue adhesive capacity; the peptide fragment-containing cyanoacrylate derivative can be independently used or can be combined with other cyanoacrylate substances for use; moreover, the peptide fragment-containing cyanoacrylate derivative can be used as a degradable medical adhesive for adhering the wound, stopping bleeding for the large-area wound, as well as closing wounds of the internal organs and soft tissues; and besides, the peptide fragment-containing cyanoacrylate derivative also can be used as a universal modification way of peptide for slow release, and further also can be used for preparing tissue engineering materials.

Description

technical field [0001] The present invention relates to an α-cyanoacrylic acid derivative, in particular to an α-cyanoacrylic acid derivative containing a peptide fragment. The ethylenic bonds in this derivative can rapidly undergo intermolecular polymerization under anion-initiated conditions, and produce adhesive bonding ability, which can be used alone or in combination with other cyanoacrylate substances as biodegradable medical adhesives. It is used for wound adhesion, hemostasis of large-area wounds, and closure of internal organs and soft tissue wounds. It can also be used as a general modification of peptides for sustained release purposes, and can also be used to prepare tissue engineering materials. Background technique [0002] α-cyanoacrylate molecules, because of the combination of cyano and ester groups on the α carbon atom in its structure, the double bond electron cloud density is very low, and it has strong electric absorption. In the presence of amino grou...

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Problems solved by technology

[0005] However, these alkyl α-cyanoacrylates have some disadvantages, such as high polymer hardness, low flexibility, and poor skin compliance; Double bonds are polymerized, and the carbon-carbon bonds have a high energy level and are not easy to be destroyed. Therefore, this type of polymer degrades very slowly, which also leads to foreign body reactions, which may cause new inflammation, and even hinder further wound healing. Their utility as surgical adhesives / sealants

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