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Application of tanshinone IIA to preparing drugs or cosmetics for inhibiting propionibacterium acnes

A technology of Propionibacterium acnes and tanshinone, which is applied in the field of compounds, can solve the problems of surrounding tissue damage, hair follicle wall structure damage, hair follicle integrity damage, etc., and achieve the effect of simple application and easy use

Inactive Publication Date: 2013-05-08
LB COSMECEUTICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] (5) Propionibacterium acnes can secrete a large amount of esterase and protease, thus causing damage to the structure of the hair follicle wall
[0020] (7) The lack of linoleic acid causes the generation of free radicals, O 2 、H 2 o 2 and OH · causing damage to the surrounding tissue and disruption of the integrity of the hair follicle

Method used

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  • Application of tanshinone IIA to preparing drugs or cosmetics for inhibiting propionibacterium acnes
  • Application of tanshinone IIA to preparing drugs or cosmetics for inhibiting propionibacterium acnes
  • Application of tanshinone IIA to preparing drugs or cosmetics for inhibiting propionibacterium acnes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Tanshinone IIA inhibits Propionibacterium acnes

[0038] Experimental strain: Propionibacterium acnes (ATCC6919)

[0039] Medium:

[0040] (1) Liquid medium: tryptone 10g / L, beef extract 10g / L, glucose 5g / L, NaCl 5g / L, yeast extract 3g / L, sodium acetate 3g / L, soluble starch 1g / L, cysteine Dissolve 0.5g / L hydrochloride in distilled water, adjust the pH to 6.8±0.2, and autoclave at 115°C for 20min. (2) Solid medium: add agar 15g / L on the basis of liquid medium.

[0041] Experimental method: Determination of inhibition zone

[0042] Propionibacterium acnes was inoculated in solid medium, and activated under anaerobic conditions at 37°C for 2 days. After activation, the plaque was directly diluted with physiological saline to prepare a bacterial suspension. Take 0.5ml of the activated bacterial suspension in liquid medium, and culture it under anaerobic conditions at 37°C for 2 days, which is the experimental bacterial suspension. The experimental method adop...

Embodiment 2

[0048] Example 2 Tanshinone IIA inhibits Propionibacterium acnes MIC value determination

[0049] Experimental strain: Propionibacterium acnes (ATCC6919)

[0050] Medium: (1) Liquid medium: tryptone 10g / L, beef extract 10g / L, glucose 5g / L, NaCl 5g / L, yeast extract 3g / L, sodium acetate 3g / L, soluble starch 1g / L, semi Cystine hydrochloride 0.5g / L, dissolved in distilled water, adjusted to pH 6.8±0.2, autoclaved at 115°C for 20min. (2) Solid medium: add agar 15g / L on the basis of liquid medium.

[0051] Experimental method: Determination of the minimum inhibitory concentration (MIC value) of traditional Chinese medicine extracts

[0052] Propionibacterium acnes was inoculated in solid medium, and activated under anaerobic conditions at 37°C for 2 days. After activation, the plaque was directly diluted with physiological saline to prepare a bacterial suspension, and the bacterial suspension was diluted with liquid medium. Make the final bacterial concentration l0 5 CFU / mL.

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Abstract

The invention discloses an application of tanshinone IIA in preparing drugs or cosmetics for preventing or treating comedo caused by reproduction of propionibacterium acnes. The tanshinone IIA is capable of effectively treating the acnes caused by the reproduction of the propionibacterium acnes. The tanshinone IIA is obtained from dry roots or rhizomes of Salvia miltiorrhiza Bge, has low toxicity to human bodies and has a high inhibition effect on the propionibacterium acnes; and therefore, the tanshinone IIA can be prepared into various drug forms for external use and cosmetics, and has an excellent application prospect.

Description

technical field [0001] The present invention belongs to the use of compounds, and relates to the use of tanshinone IIA in the preparation of P. acnes inhibitors, in particular to the use of tanshinone IIA in the preparation of medicines or skin care products for treating or preventing acne caused by the propagation of Propionibacterium acnes. Background technique [0002] Tanshinone IIA is an important active ingredient of the traditional Chinese medicine Danshen (Salvia miltiorrhiza Bge). Salvia miltiorrhiza Bunge (Salvia miltiorrhiza Bunge) is a traditional Chinese medicine in my country, which belongs to the genus Salvia (Lemiaceae, Labiatae). [0003] Tanshinone IIA is an orange-red needle-like crystal, and its chemical structure is as follows: [0004] [0005] Acne, also known as acne, is a complex, chronic and universal sebaceous gland dysfunction disease that mainly occurs on the face, chest and back of adolescents. It initially appears as a pointed protrusion c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P31/04A61P17/10A61K8/63A61Q19/00A61Q19/10C11D9/50C11D9/26
Inventor 孙常磊朱丽平李成亮
Owner LB COSMECEUTICAL TECH CO LTD
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