Novel hydrogel scar patch and its preparation process

Abstract

The invention relates to a novel hydrogel scar patch and its preparation process. The hydrogel scar patch is composed of a support layer, a hydrogel layer and an isolation layer. The scar patch is characterized in that the hydrogel layer consists of the following components by mass: 0.4-3% of a water-soluble high polymer compound Carbomer, 4-8.5% of polyacrylic acid resin, 0.1-1% of polyvinyl alcohol, 0.1-2% of sodium carboxymethyl cellulose, 0.01-0.5% of polyvinyl pyrrolidone, 20-30% of a moisturizing agent, 0.03-0.3% of a cross-linking agent, 0.02-0.3% of EDTA, 0.05-1% of a bacteriostatic agent, 50-70% of deionized water, a proper amount of a pH conditioning agent, and 1-20% of a drug.

Description

technical field [0001] The invention relates to the field of medical cosmetology, in particular to an external skin preparation applied to soften various scars on the skin surface, inhibit hyperplasia, flatten, relieve itching and fade. Background technique [0002] Scars are the inevitable result of healing of various wounds, but if the healing is insufficient or excessive, scars will be formed, and if the scars continue to proliferate, hypertrophic scars can occur. According to the degree of damage caused by various injury factors and the physique of the injured, the following types of scars can be caused: superficial scars, atrophic scars, sunken scars, hypertrophic scars, keloids, especially for people with scar constitution, scars Especially obvious. Scars will bring great inconvenience to patients, such as hypertrophic scars caused by burns, which can cause local itching, pain, and even dysfunction, which seriously troubles patients. The prevention and treatment of s...

AI Technical Summary

Problems solved by technology

[0004] However, the above-mentioned silicone gel scar stickers have the following problems: 1. Weak hydration: First, this type of product does not contain moisture, and its hydration is blocked by silicone gel products through skin moisture evaporation, and the moisture is passive. Retained in the scar skin, the hydration effect is limited; secondly, due to some serious injuries, such as third-degree burns, skin sweat glands, etc., the water evaporation is limited, and the hydration effect is greatly weakened; 2. Lack of protective function for the scar body: For scars, especially severe hypertrophic scars and keloids, the skin on the surface is often damaged, and there may be tiny cracks or microbial infections, while silicone gel products lack antibacterial or bactericidal functions, and because such products are applied to scars Due to the relatively high humidity and temperature, it is easy to cause the growth of microorganisms and cause inflammation of the scar; 3. Repeated use will affect the sanitation and hydration effect: the instructions for silicone gel scar stickers generally indicate that they can be used repeatedly, so , the skin contact surface of this kind of product is easy to adhere to microorganisms, skin oil, dander, affecting product hygiene and hydration; 4. Difficulty in combination medication: it is difficult to combine silicone gel scar stickers, including other ingredients that can inhibit scars Combination of ingredients, drug combination, improve curative effect

Although the silicone gel membrane has a certain ability to pass through water vapor, the molecular weight of the drug or other effective ingredients for scars is usually dozens or hundreds of times that of the water molecule, so the permeability of the silicone gel to the membrane drug is even Yes, but very limited, it is not very ideal to use silicone gel membrane as a carrier for transdermal absorption

[0005] After reviewing domestic and foreign literature and related materials, there is no clear report on the hydrogel scar patch based on the hydrogel patch.