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Nanoparticle-guided radiotherapy

A radiation therapy, particle technology, applied in the field of nanoparticle-guided radiation therapy, which can solve problems not specifically mentioned

Inactive Publication Date: 2013-05-01
DANMARKS TEKNISKE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A method for treatment in which healthy tissue is preserved from radiation is not specifically mentioned in the application

Method used

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  • Nanoparticle-guided radiotherapy

Examples

Experimental program
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Effect test

example I

[0272] Example 1 - Preparation of liposomes according to the invention

[0273] a. General example of the preparation method of liposomes using ionophores

[0274] If the CT contrast agent is loaded into liposomes with the help of ionophores, the preferred preparation process includes the following steps:

[0275] a) Mixing selected lipids, eg first by dissolving them in chloroform and then drying to obtain a thin film of lipids.

[0276] b) Treating the lipid membrane with a buffer solution (the buffer solution includes a chemical compound that will reduce the metal salt to the metal in the zero-valent oxidation state, or with the metal in the oxidation state above zero ( Metal compounds in oxidation states such as +1, +2, +3) form an insoluble salt, or a combination of reduction and formation using a low solubility salt) for hydration.

[0277] c) Utilize a method to obtain liposomes with a preferred size of 20 to 150 nm as assessed by cryo-transmission electron microscopy...

example II

[0331] Example II - Preparation of Nanoscale Particles Useful in the Methods of the Invention

[0332] a. Synthetic procedure for obtaining gold nanoparticles (AuNPs) with different sizes from 16-80 nm

[0333] Material:

[0334] Gold(III) tetrachlorohydrogen tetrahydrate was purchased from Wako Pure Chemical Industries Ldt. Sodium acrylate, sodium hydroxide, nitric acid, and hydrochloric acid were purchased from Sigma-Aldrich. MilliQ water (Millipore, Bedford, MA) was used throughout the preparation of gold nanoparticles. All material was used without further purification.

[0335] Characterization:

[0336] Particles were analyzed by dynamic light scattering and zeta potential measurements (Zetasizer Nano; Malvern Instruments, Malvern, UK) together with their UV-Vis spectroscopy (Unicam Helios Uni-9423). characterization. Tecnai T20G2 (FEI Corporation, USA) transmission electron microscope and atomic force microscope (PSIAXE150Park Systems, Korea) were used to visual...

example III

[0370] Example III - Preparation of Lipid-Coated Nanoscale Particles Useful in the Methods of the Invention

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Abstract

The present invention relates to a method and nano-sized particles for image guided radiotherapy (IGRT) of a target tissue. More specifically, the invention relates to nano-sized particles comprising X-ray-imaging contrast agents in solid form with the ability to block x-rays, allowing for simultaneous or integrated external beam radiotherapy and imaging, e.g., using computed tomography (CT).

Description

[0001] Every patent and non-patent reference cited in this application is hereby incorporated by reference in its entirety technical field [0002] The present invention relates to a method and nanoparticles for image-guided radiation therapy (IGRT). More precisely, the present invention relates to nanoparticles comprising computed tomography (CT)-imaging contrast agents in solid form with x-ray blocking capabilities, which allow simultaneous or integrated computed tomography ( CT)-imaging with external beam radiation therapy. Background technique [0003] Cancer is a leading cause of death. Currently, on a worldwide basis, 1 in 8 people dies from cancer. Another devastating fact about cancer is that it kills people of all ages. Cancer is caused by the uncontrolled growth of cells, and curative treatment of cancer aims at removing or destroying these malignant and growing cells. [0004] Radiation Therapy [0005] Three different approaches are commonly used to treat c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/10A61K49/00A61B6/03A61B34/20A61B90/00
CPCA61B6/4092A61K49/0409A61K49/0423A61B5/0071A61B5/055A61N5/1067B82Y5/00A61B8/481A61B5/0035A61N2005/1061A61B6/481A61B6/037A61B6/032A61N5/1039A61N5/1049A61K49/0428A61B5/0075
Inventor 托马斯·拉尔斯·安德雷森莫滕·阿尔布雷克特森
Owner DANMARKS TEKNISKE UNIV
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