Method for detecting abnormal numbers of five chromosomes
A chromosome number and chromosome technology, applied in the field of detection, can solve the problems of high technical requirements, high fees, and long time consumption, and achieve the effects of low cost, short time consumption, high sensitivity and accuracy
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[0068] figure 1 Case analysis of chromosomal aneuploidy. The results of GeXP capillary electrophoresis analysis of the DNA samples (50-100ng) shown in the figure are from top to bottom: normal female DNA sample; monosomy of chromosome X; trisomy of chromosome 13; trisomy of chromosome 18 and chromosomal 21 Chromosome trisomy. Chromosomal aneuploidy can be detected by quantitative analysis. For example, by observing the relative height of the specific peaks of each chromosome in the black box, it can be clearly shown that the difference in peak height corresponds to chromosome aneuploidy or sex; in addition, by comparing and calculating the relative peak area of each specific peak of each chromosome, the chromosome can be more accurately displayed Aneuploidy (see "Example 4, Data Analysis")
[0069] figure 2 Quantitative analysis of chromosome number in normal samples. The relative copy number of each gene (primer pair) on each chromosome (chromosomes 13, 18 and 21) rep...
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