Piracetam pharmaceutical co-crystal taking 3,4-dihydroxy-benzoic acid as precursor and preparation method of piracetam pharmaceutical co-crystal

Abstract

The invention belongs to the technical field of pharmaceutical co-crystals, and particularly relates to a piracetam pharmaceutical co-crystal taking 3,4-dihydroxy-benzoic acid as a precursor and a preparation method of the piracetam pharmaceutical co-crystal. A space group of the pharmaceutical co-crystal is a monoclinic system, and three 3,4-dihydroxy-benzoic acid molecules (1) and a piracetam molecule (2) are combined through hydrogen bonds to form a basic structural unit of the piracetam pharmaceutical co-crystal. In a pharmaceutical co-crystal preparation process, a selected solvent is methanol; an adopted method is a solvent room-temperature volatilization method; and as a boiling point of the selected organic solvent is lower, a crystal is precipitated in a solvent volatilization process. The prepared pharmaceutical co-crystal inherits the characteristic of the traditional bulk pharmaceutical for repairing nerve cells of a brain function injured patient, and the dissolvability, the stability and the bioavailability of the pharmaceutical co-crystal are improved obviously.

Description

technical field [0001] The invention belongs to the technical field of drug co-crystals, and in particular relates to a piracetam drug co-crystal with 3,4-dihydroxybenzoic acid as a precursor and a preparation method thereof. Background technique [0002] In 1894, E. Fischer of Germany proposed the "lock-key" model based on the idea of ​​"selective interaction between molecules", which was the prototype of modern supramolecular science theory. In 1937, German K.L.Wolf et al. created the term "supramolecular" to describe highly ordered entities formed by the association of molecules. In a general sense, any collection of molecules has interactions, so people often refer to them as The structural level of matter aggregation state is called "supramolecular". It was not until 1978 that Professor J.M.Lehn of France finally proposed the complete concept of "supramolecular chemistry" based on the traditional research on the host-guest system rooted in organic chemistry. Supramole...

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Problems solved by technology

[0005] Piracetam is a drug for improving brain metabolism, which belongs to the cyclic derivative of γ-aminobutyric acid. It is used for the treatment of cerebrovascular disease and peripheral vascular disease. Cognitive abilities, but not in people with severe dementia

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