Modified snake venom gelling agent and preparation method thereof

Abstract

The invention relates to the technical field of medicine, and particularly discloses a modified snake venom gelling agent and a preparation method thereof. The modified snake venom gelling agent comprises the following components by mass percent: 0.1-2% of modified snake venom, 30-70% of alcohol, 0.05-0.1% of sodium chloride, 0.1-2.5% of suspending agent and 0.1-0.3% of preservative, and the balance of deionized water. As no snake venom gelling agent without sensitization and with a high analgesic effect is not available in the existing gelling agent products, the gelling agent for overall snake venom is prepared by taking the appropriate suspending agent, preservative, the modified snake venom and sodium chloride as raw materials, has higher analgesic effect and no sensitization, and is superior to the existing similar products.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a modified snake venom gel and a preparation method thereof. Background technique [0002] Snake venom is a liquid secreted by poisonous snakes from the venom glands. The main component is toxic protein, which accounts for 90% to 95% of the dry weight. It contains about 20 kinds of enzymes and toxins. In addition, it also contains some small molecular peptides, amino acids, carbohydrates, lipids, nucleosides, biogenic amines and metal ions. [0003] Snake venom is a substance rich in pharmacological treasures, and many components have strong pharmacological effects, so it is more and more widely used in clinical medicine, such as cancer treatment and anti-cancer, hemostasis and anticoagulation, poisonous drugs and Analgesics, preparation of antivenom, blood pressure and fiber reduction, thrombolysis, treatment of blood stasis head tonic, etc. Among them, it is more common to u...

AI Technical Summary

Problems solved by technology

[0005] There are many pharmaceutical gels in existing products, but there is no report about snake venom gel products

Different from the properties of drugs in existing pharmaceutical gels, snake venom has the commonality of proteins and polypeptides. Any strong acid, strong alkali and heavy metal salts that can cause protein precipitation and denaturation can destroy snake venom. Snake venom is also susceptible to oxidants, reduction The destruction of agents, proteolytic enzymes, etc., resulting in changes in the basic molecular structure and three-dimensional properties of proteins, toxins, and enzymes in snake venom, and the loss of their original pharmacological effects

However, in order to consider its quality, the preparation of the gel needs to add a variety of excipients, and these excipients are likely to have an adverse effect on the efficacy of the snake venom and the quality of the gel product (such as stability, spreadability, viscosity)

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