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Electrically responded microfluid self-driven microfluidic chip and preparation method thereof

A microfluidic chip and microfluidic technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., to achieve good application prospects, cost reduction, and simple operation.

Inactive Publication Date: 2013-04-24
SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, it is difficult for conventional technologies to intelligently drive microfluids in microchannels. Therefore, by using an external electric field to control the change of surface wettability to drive microfluidics in a microfluidic chip, a convenient, fast, and High-efficiency and low-cost microfluidic drive technology should be one of the research directions on how to control microfluidics on microfluidic chips, and there has been no substantial breakthrough yet

Method used

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  • Electrically responded microfluid self-driven microfluidic chip and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0022] The microstructure and microchannel pattern of the two-layer chip of the microfluidic chip with controllable microfluidic flow are designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer polymethyl methacrylate (PMMA) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, glued, and pressure-sealed to form a smart micropump based on a microfluidic chip. The sample solution is added to the sample injection hole of the microfluidic chip, and the solution enters the microchannel driven by the external peristaltic pump. In the micropump area of ​​the micro...

Embodiment 2

[0024] The microstructure and microchannel graphics of the two-layer chip of the centrifugal microfluidic chip were designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer disc-shaped polycarbonate (PC) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, glued, and pressure-sealed to form a smart micropump based on a microfluidic chip. The sample solution is added to the sample injection hole of the microfluidic chip, and the solution enters the microchannel driven by the external peristaltic pump. In the micropump area of ​​the microchannel, the electrica...

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Abstract

The invention relates to an electrically responded microfluid self-driven microfluidic chip and a preparation method thereof. Microstructures and microchannels are arranged on the surface of the microfluidic chip; the surfaces of the microchannels are modified through electric responsiveness molecules; under the excitement of an external electric field, the reversible change of surface morphology and chemical construction of the microchannels causes the change of surface wettability; microfluids are controlled to move from bottom to top on the surfaces of the microchannels so as to realize the spontaneous flowing of the microfluids; and the microfluidic chip is mainly applied in the related fields, such as electrophoretic separation, chromatographic separation, immunoassay, reaction and the like. The microfluidic chip is easy to operate, realizes the self-driving of the microfluids from bottom to top, largely reduces the driving cost of the microfluids, has the characteristics of portability, economy, rapidness and high efficiency, and provides a brand new non-driving flowing technology for the driving of the microfluids.

Description

technical field [0001] The invention relates to an electrically responsive microfluidic self-driven microfluidic chip and a preparation method thereof. The surface of the microfluidic chip has microstructures and microchannels, and the surface of the microchannel is modified by electrically responsive molecules. Under stimulation, the reversible changes in the surface morphology and chemical configuration of the microchannel lead to changes in surface wettability, controlling the movement of microfluids from bottom to top on the surface of microchannels, thereby realizing the spontaneous flow of microfluids, mainly used in electrophoresis Separation, chromatographic separation, immunoassay, reaction and other related fields. Background technique [0002] As a new type of analysis platform, microfluidic analysis chip has the advantages of miniaturization, automation, integration, convenience and speed, and has been widely used in many fields, such as cell biology, analytical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 沙俊
Owner SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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