Chromatographic sheet with self-repairing function and preparation method thereof

Abstract

The invention discloses a chromatographic sheet with a self-repairing function and a preparation method thereof. A self-repaired modified silica gel with a hydrogen-bond interaction is served as an absorbing agent, a high molecular polymer which contains an amide or is liable to obtain a hydrogen-bond functional group is connected to the silica gel to obtain the modified silica gel, and the modified silica gel is aggregated to obtain a supramolecular structure in a reversible cross-linking state through multiple hydrogen-bond interactions among modified silica gel molecules, so that minor damages and microcracks of the chromatographic sheet can be self-inspected and self-repaired in process of placing the chromatographic sheet for a long time or carrying out activating, plate washing and plate running on an adsorbent, and the performance is stable and reliable; furthermore, a Rf value has a reproducibility that the general chromatographic sheet can not reach, so that the detection result is more accurate; and meanwhile, the chromatographic sheet can be self-repaired without outside intervention, so that the recycling times of the plate is increased greatly and the cost is saved.

Description

technical field [0001] The invention relates to a thin-layer chromatographic plate, in particular to a self-repairable thin-layer chromatographic plate and a preparation method thereof. Background technique [0002] Thin-layer chromatography belongs to the category of liquid chromatography and is a fast, simple, high-resolution and high-efficiency chromatography developed in recent years. The common practice of thin-layer chromatography is to coat an adsorbent (such as silica gel powder, alumina powder, etc.) on the surface of a glass plate or a metal plate to form a thin layer, and then apply a sample at one end of the thin layer. Through the adsorbent, so as to achieve an effective separation effect. The thin-layer chromatography plate prepared by Merck is mainly aimed at the sensitivity and surface mechanical properties of the thin-layer chromatography plate. Although the possible cracks or damage of the thin-layer chromatography plate during use are considered, it only ...

AI Technical Summary

Problems solved by technology

The thin-layer chromatography plate prepared by Merck is mainly aimed at the sensitivity and surface mechanical properties of the thin-layer chromatography plate. Although the possible cracks or damage of the thin-layer chromatography plate during use are considered, it only strengthens the thin-layer chromatography plate. The surface strength of the thin-layer chromatographic plate does not take into account some changes that occur when the thin-layer chromatography plate is placed for a long time or under the action of solvents, and it is still impossible to avoid slight damage or generation of Microcracks reduce the quality and performance of the TLC plate, poor reusability, poor reproducibility, and corresponding increase in experimental error, thus affecting the experimental effect and high economic cost