Procationic/cationic liposome curcumin preparation for interventional treatment of liver cancer and preparation method thereof

Abstract

Pre-cationic / cationic liposomal curcumin preparation for interventional treatment of liver cancer and preparation method thereof The present invention relates to a cationic / pre-cationic liposomal curcumin preparation for interventional treatment of liver cancer and a preparation method thereof. It is characterized in that, the medicine in the preparation is made from the following components: curcumin 1mg, egg yolk lecithin 3.0g, cholesterol 1.0g, octadecylamine 0.2g / [2-[[4-[(carboxymethyl)disulfide ]-1-iminobutyl]amino]ethyl]cholesteryl carbamate (CHETA) 0.05g, vitamin E 0.3g, pH 6.6 phosphate buffered saline solution 20mL. Preparation method: take egg yolk lecithin, cholesterol, octadecylamine / CHETA and vitamin E in a pear-shaped bottle, add 10 mL of ether, shake, and then add 5 mL of curcumin-containing absolute ethanol solution, and put it on a rotary evaporator at 35°C Evaporate to dryness to form a film, then add 20 mL of phosphate buffered saline solution with a pH value of 6.6, rotate for 20 minutes to dissolve the film, leave it for 3 hours to fully hydrate, sonicate for 3 minutes, and pass through a 0.22 μm filter membrane to obtain cationic / precationic liposomal curcumin . The two preparations are used to treat liver cancer through interventional administration, and have higher therapeutic effects and lower side effects on various stages of liver cancer.

Description

Technical field: [0001] The invention belongs to the field of new drug development of traditional Chinese medicines, and in particular relates to a procation / cation liposome curcumin preparation for interventional treatment of liver cancer and a preparation method thereof. Background technique: [0002] Primary liver cancer (primary carcinoma of the liver) is a cancer that originates from hepatic parenchymal cells or intrahepatic cholangiocytes, and hepatocellular carcinoma (HCC) is the most common clinical form. Because of its insidious onset, rapid development, and high mortality rate, it is commonly known as the "king of cancer" and has become an enemy that threatens human health. Liver cancer is the fifth most common malignant tumor and the third most common cause of cancer death in the world. my country is one of the high incidence areas of liver cancer, about 50% of which occur in China. [0003] Surgery, radiation therapy (radiotherapy), and chemotherapy (chemotherap...

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Problems solved by technology

[0010] In order to solve the problems of poor long-term curative effect and high toxicity in the existing interventional preparations for the treatment of liver cancer, this patent uses curcumin, an edible and non-toxic active ingredient in turmeric, an anticancer traditional Chinese medicine, as interventional therapy Combining it with liposomes and intervening in the treatment of liver cancer can well solve the above problems