Traditional Chinese medicine compound eye drops for preventing cataract and preparation method thereof

A technology of cataract and eye drops, which is applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of poor curative effect and high cost, and achieve the improvement and treatment of blurred vision, quick onset, curative effect

Active Publication Date: 2013-04-17
四川欣亿康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In order to overcome the defect of poor curative effect and high cost of surgical therapy for the initial stage and expansion stage of cataract, and to solve the problem of poor curative effect of western medicine in the treatment of this chronic disease (ie cataract), the primary purpose of the present inventio...

Method used

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  • Traditional Chinese medicine compound eye drops for preventing cataract and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0034] A traditional Chinese medicine compound eye drop for preventing and treating cataract, prepared by the following steps:

[0035] (1) Mix 500g of cassia seed, 300g of Budisma japonica, 300g of breviscapita and 500g of rutabaga, add water and decoct at 80°C, decocting for 3 times, each decocting for 0.5 hours, and the amount of water added each time is four herbs 6 times of the mass sum; combine the extracts, filter and concentrate to a relative specific gravity of 1.08-1.09, then add ethanol until the volume ratio of ethanol reaches 70%, centrifuge to take the supernatant, and then spin evaporate to recover ethanol to obtain a liquid extract ;Put the liquid extract on polyamide column chromatography, elute successively with 70% (volume ratio) and 90% (volume ratio) ethanol aqueous solution, collect and combine the eluents, and then spin evaporate and recover ethanol to obtain a dry paste; Dissolve the dry paste with borate buffer (pH 8.20);

[0036] (2) Mix 10g borneol ...

Embodiment 2

[0039] A traditional Chinese medicine compound eye drop for preventing and treating cataract, prepared by the following steps:

[0040](1) Mix 450g cassia seed, 400g Budisma japonica, 550g breviscapita and 200g rutabaga, add water and decoct at 90°C, decocting for 3 times, each decocting for 0.5 hours, the amount of water added each time is four herbs 6 times of the mass sum; combine the extracts, filter and concentrate to a relative specific gravity of 1.08-1.09, then add ethanol until the volume ratio of ethanol reaches 70%, centrifuge to take the supernatant, and then spin evaporate to recover ethanol to obtain a liquid extract ;Put the liquid extract on polyamide column chromatography, elute successively with 70% (volume ratio) and 90% (volume ratio) ethanol aqueous solution, collect and combine the eluents, and then spin evaporate and recover ethanol to obtain a dry paste; Dissolve the dry paste with borate buffer (pH 8.20);

[0041] (2) Mix 10g borneol with 10g Tween-80...

Embodiment 3

[0044] A traditional Chinese medicine compound eye drop for preventing and treating cataract, prepared by the following steps:

[0045] (1) Mix 600g cassia seed, 250g Budisma japonica, 400g breviscapita and 350g rutabaga, add water and decoct at 100°C, decocting for 3 times, each decocting for 0.5 hours, and the amount of water added each time is four herbs 6 times of the mass sum; combine the extracts, filter and concentrate to a relative specific gravity of 1.08-1.09, then add ethanol until the volume ratio of ethanol reaches 70%, centrifuge to take the supernatant, and then spin evaporate to recover ethanol to obtain a liquid extract ;Put the liquid extract on polyamide column chromatography, elute successively with 70% (volume ratio) and 90% (volume ratio) ethanol aqueous solution, collect and combine the eluents, and then spin evaporate and recover ethanol to obtain a dry paste; Dissolve the dry paste with borate buffer (pH 8.20);

[0046] (2) Mix 10g borneol with 20g Tw...

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Abstract

The invention discloses a traditional Chinese medicine compound eye drop for preventing cataract and a preparation method of the traditional Chinese medicine compound eye drop. The preparation raw materials of the traditional Chinese medicine compound eye drop comprise the following ingredients in parts by weight: 45-60 parts of semen cassiae, 25-40 parts of flos buddlejae, 30-55 parts of herba erigerontis, 20-50 part of nux prinsepiae and 1 part of borneol. The traditional Chinese medicine compound eye drop is prepared by traditional Chinese medicines such as semen cassiae, flos buddlejae, borneol, herba erigerontis, nux prinsepiae and the like, and has the efficacy of removing slight corneal opacity and improving eyesight, and is used for improving and treating blurred vision and senile cataract. The compound eye drop has certain innovativeness in prescription selection and a certain social and economic value. Medicines for treating cataract currently are mainly prifenoxine (pirenoxine sodium) eye drop, and the preparation pharmacopoeia record for preventing cataract in a traditional Chinese medicine field is not available. The traditional Chinese medicine compound eye drop has the advantage of the traditional Chinese medicine prescription, and plays the characteristic of subtle droplet administration. The eye drop prepared by the method changes the history of no special efficacy medicines to treat senile cataract.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine compound eye drop for preventing and treating cataracts and a preparation method thereof. Background technique [0002] Cataract is one of the common eye diseases. It is the turbidity of the lens in the eye from transparent to opaque, which prevents light from entering the eye and affects vision. The initial opacity of cataract has little effect on vision, and then it will gradually increase, and finally significantly affect vision or even blindness. [0003] There are many causes of cataract, including congenital, traumatic, concurrent, senile, etc., among which senile cataract (SC, the same below) is the most common. In recent years, senile cataract is also called age-related cataract (age-related cataract), its onset is more common after the age of 50, and the incidence rate increases with age. 70%, 80% over the age of 7...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P27/12
Inventor 杨凤琼罗宪堂叶殷殷曹智启陈桂江辛增辉
Owner 四川欣亿康药业有限公司
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