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Passiflora edulis sims stem-leaf extract as well as pharmaceutical composition and antidepressant action of extract

A technology for extracts of Passiflora japonica and leaves, which is applied in the field of medicine, can solve the problems of no Passiflora japonica extract and its active compounds, etc., and achieves the effects of significant curative effect, convenience for patients, and low dosage.

Active Publication Date: 2013-04-17
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, in the prior art, there is no report on the activity of the extract of Passiflora japonica and its active compounds as a drug for the treatment of anxiety and depression

Method used

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  • Passiflora edulis sims stem-leaf extract as well as pharmaceutical composition and antidepressant action of extract
  • Passiflora edulis sims stem-leaf extract as well as pharmaceutical composition and antidepressant action of extract
  • Passiflora edulis sims stem-leaf extract as well as pharmaceutical composition and antidepressant action of extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Separation and enrichment of cycloaltinane-type triterpenoids, flavonoids and their glycosides from Passiflora japonica:

[0030] Gather the stems and leaves of Passiflora japonica and dry them, weigh 3.6 kilograms, make coarse powder, extract with reflux of 90% ethanol, reclaim ethanol after filtering out ethanol, obtain extract extract; extract extract is dispersed in water, Petroleum ether or ethyl acetate extraction and degreasing; the remaining aqueous phase is loaded with macroporous resin, washed with water until it is colorless, and then eluted with 80% ethanol to obtain a total extract that is 78 grams of active extracts rich in triterpenoids and flavonoids , the total yield is about 2.17%.

[0031] The above-mentioned extract contains the following compounds cycloaltinane-type triterpenes, flavonoids and glycosides as main components.

[0032]

[0033] Among them, R1~R4 are aglycones and glycosides formed by hydrogen atoms, hydroxyl groups, various sugars,...

Embodiment 2

[0035] Screening of antidepressant activity of extracts from the stems and leaves of Passiflora violet:

[0036] Passiflora stalks and leaves of Passionflower were dried separately, made into a coarse powder, each took 20.0 grams of samples, and extracted with 70% acetone water under reflux for 3 hours. The extract was filtered, and the acetone water solvent was recovered to obtain the extract extract Passionflower stem extract (XFLJ, 5.6 grams, extraction rate 28.0%) and Passionflower leaf extract (XFLY, 7.3 grams, extraction rate 36.5%). The results showed that the antidepressant activity of the high-dose XFLY group (crude drug dose 10g / kg) was poor, which may be related to its sedative effect (Table 1 and Table 2).

[0037]

[0038]

[0039] Compared with blank: *P<0.05

[0040] It can be seen from Table 1 that the positive control clomipramine and the XFLY low-dose group (crude drug dose 2g / kg) were administered intragastrically for 7 days, which can significantly s...

Embodiment 3

[0044] The antidepressant activity of the three main components of purple fruit passionflower:

[0045] After harvesting, the stems and leaves of Passiflora japonica are dried, beaten into a coarse powder, weighed to obtain 3.6 kg, extracted twice with 10 liters of 90% ethanol under reflux, each time for 3 hours, combined with the ethanol extract obtained by filtration, and decompressed Concentrate and evaporate the ethanol solution, add appropriate amount of water to a total volume of about 2.5 liters of water suspension. Then extract 3 times with ethyl acetate, 1.5 liters each time, and apply the D101 macroporous resin to the extracted water; first wash the resin column with water until it is colorless, then elute the macroporous resin column with 80% ethanol, collect the ethanol washing Remove parts, concentrate to dry paste, and weigh 78 grams, which is the total extract rich in triterpenoids and flavonoids.

[0046]The total extract was subjected to repeated silica gel c...

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Abstract

The invention discloses passiflora edulis sims stem-leaf extract, an active compound of the extract, a pharmaceutical composition of the extract, a preparation method of the extract and application of the extract in preparing an antidepressant healthcare product. The passiflora edulis sims stem-leaf extract is applied to sedative and antidepressant relevant products by adopting ring-aalten alkyl triterpene, flavone and glucoside of the flavones as index components. The passiflora edulis sims plant is the plant of fruit planting industry and garden greening industry, which is easy to plant, and the materials are easy to obtain. The process for extracting the enriched triterpene and flavone extract is simple, and applicable to the industrial production. Moreover, the passiflora edulis sims stem-leaf extract has certain sedative and antidepressant activity, and is applied to developing the relevant sedative and antidepressant products.

Description

Technical field: [0001] The invention belongs to the technical field of medicines, in particular, it relates to the stem and leaf extract of Passiflora violet, its further active compounds, its pharmaceutical composition, their preparation method, and their application in the preparation of antidepressants. Background technique: [0002] Passiflora (Passiflora) is the largest genus of Passifloraceae (Passifloraceae). There are more than 400 species of plants in the whole genus. The plants in this genus are all perennial herbs or woody vines, of which there are about 60 edible species. It is native to tropical America, and most of the other species are produced in tropical Asia. There are 20 species and 2 varieties recorded in "Flora of China". my country introduced this genus plant from the Philippines into Taiwan for planting in 1913. At present, it is cultivated in Taiwan, Fujian, Guangdong, Guangxi and Yunnan provinces (districts). Fruit passion fruit (Passiflora edulis f...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K31/7048A61K31/7032A61P25/24A61P25/22A61P25/20A23L1/30A61K127/00A61K135/00
Inventor 胡江苗周俊尚建华王聪赵云丽许凤清杨柳崔娟刘玉清谭仕杰
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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