Chitosan gel for removing acne scars as well as preparation method and medical application thereof
A technology of chitosan gel and chitosan, which is applied in the direction of pharmaceutical formulations, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of reducing the action time, small content, and deterioration of gel properties
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Embodiment 1
[0058] Embodiment 1, anti-acne scar chitosan gel and preparation method thereof
[0059] Recipe: Chitosan 10g (viscosity average molecular weight 60,000, degree of deacetylation ≥ 90%)
[0060] Glycerin 8g
[0061] 37% mixture of hydrochloric acid and glacial acetic acid (V:V=5:1) appropriate amount
[0062] Purified water was added to 100g.
[0063] Preparation method: in an environment with a cleanliness of 100,000, take 80ml of purified water, add chitosan with a molecular weight of 60,000 in the prescribed amount, stir and add an appropriate amount of hydrochloric acid-acetic acid mixed solution to make the reactant form a gel. And make the pH value of the gel at 4.2-4.5, add glycerin and stir evenly, degas, fill in aluminum-plastic hose and seal, and further sterilize with 10-11KGy dose of cobalt-60 radiation to obtain the present invention Chitosan gel for removing acne scars, the viscosity is 152Pa.s, and the gel has almost no acetic acid smell.
Embodiment 2
[0064] Embodiment 2, anti-acne scar chitosan gel and preparation method thereof
[0065] Recipe: Chitosan 9g (viscosity average molecular weight 50,000, deacetylation degree ≥ 95%)
[0066] Glycerin 8g
[0067] 37% mixture of hydrochloric acid and glacial acetic acid (V:V=5:1) appropriate amount
[0068] Purified water was added to 100g.
[0069] Preparation method: in an environment with a cleanliness of 100,000, take 80ml of purified water, add chitosan with a molecular weight of 50,000 in the prescribed amount, stir and add an appropriate amount of hydrochloric acid-acetic acid mixed solution to make the reactant form a gel. And make the pH value of the gel at 4.2-4.5, add glycerin and stir evenly, degas, fill in aluminum-plastic hose and seal, and further sterilize with 10-11KGy dose of cobalt-60 radiation to obtain the present invention Chitosan gel for removing acne scars, the viscosity is 91Pa.s, and the gel has almost no acetic acid smell.
Embodiment 3
[0070] Embodiment 3, anti-acne scar chitosan gel and preparation method thereof
[0071] Recipe: chitosan 7g (viscosity average molecular weight 90,000, degree of deacetylation ≥ 85%)
[0072] Glycerin 8g
[0073] Lactic acid amount
[0074] Purified water was added to 100g.
[0075]Preparation method: In an environment with a cleanliness of 100,000, take 80ml of purified water, add chitosan with a molecular weight of 90,000, stir and add an appropriate amount of lactic acid to make the reactant form a gel, and make the gel If the pH value is 4.0-4.5, add glycerin and stir evenly, degas, fill in an aluminum-plastic hose and seal it, and further sterilize it with cobalt-60 radiation at a dose of 8-9.5KGy to obtain the acne-removing scar shell of the present invention. Polysaccharide gel with a viscosity of 79 Pa.s; or degassed and filled in a vial, sealed, and further sterilized at 121°C for 15 minutes to obtain the acne-removing chitosan gel of the present...
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