Chitosan gel for removing acne scars as well as preparation method and medical application thereof

A technology of chitosan gel and chitosan, which is applied in the direction of pharmaceutical formulations, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of reducing the action time, small content, and deterioration of gel properties

Inactive Publication Date: 2013-04-17
FUZHOU QIANZHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The first point is that because chitosan has good cross-linking viscosity reaction and gelation characteristics in acidic environment, the addition of these poor biocompatibility polymer chemicals hinders the cross-linking reaction of chitosan linear molecules , also reduces the effective content of chitosan, so that the content of chitosan is all small, generally less than 3%, or even smaller, making the gel properties of the product worse;
[0007] The second point is that although the addition of these polymer substances has the effect of thickening agent, the adhesion performance of chitosan is deteriorated, and the effect on the body's own body fluids (such as sweat, acne secretions, oil, vaginal secretions, etc.) Under lower conditions, the adhesion ability of chitosan to the human body surface becomes smaller, and it is easy to be lost from the body surface, which greatly reduces the action time and greatly reduces the therapeutic effect;
[0008] The third point is that for patients with acne, the addition of these substances with poor biocompatibility will often cause irritation to the wound, sticky contact injury and heterogeneous reaction, which will adversely affect the care of the wound

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1, anti-acne scar chitosan gel and preparation method thereof

[0059] Recipe: Chitosan 10g (viscosity average molecular weight 60,000, degree of deacetylation ≥ 90%)

[0060] Glycerin 8g

[0061] 37% mixture of hydrochloric acid and glacial acetic acid (V:V=5:1) appropriate amount

[0062] Purified water was added to 100g.

[0063] Preparation method: in an environment with a cleanliness of 100,000, take 80ml of purified water, add chitosan with a molecular weight of 60,000 in the prescribed amount, stir and add an appropriate amount of hydrochloric acid-acetic acid mixed solution to make the reactant form a gel. And make the pH value of the gel at 4.2-4.5, add glycerin and stir evenly, degas, fill in aluminum-plastic hose and seal, and further sterilize with 10-11KGy dose of cobalt-60 radiation to obtain the present invention Chitosan gel for removing acne scars, the viscosity is 152Pa.s, and the gel has almost no acetic acid smell.

Embodiment 2

[0064] Embodiment 2, anti-acne scar chitosan gel and preparation method thereof

[0065] Recipe: Chitosan 9g (viscosity average molecular weight 50,000, deacetylation degree ≥ 95%)

[0066] Glycerin 8g

[0067] 37% mixture of hydrochloric acid and glacial acetic acid (V:V=5:1) appropriate amount

[0068] Purified water was added to 100g.

[0069] Preparation method: in an environment with a cleanliness of 100,000, take 80ml of purified water, add chitosan with a molecular weight of 50,000 in the prescribed amount, stir and add an appropriate amount of hydrochloric acid-acetic acid mixed solution to make the reactant form a gel. And make the pH value of the gel at 4.2-4.5, add glycerin and stir evenly, degas, fill in aluminum-plastic hose and seal, and further sterilize with 10-11KGy dose of cobalt-60 radiation to obtain the present invention Chitosan gel for removing acne scars, the viscosity is 91Pa.s, and the gel has almost no acetic acid smell.

Embodiment 3

[0070] Embodiment 3, anti-acne scar chitosan gel and preparation method thereof

[0071] Recipe: chitosan 7g (viscosity average molecular weight 90,000, degree of deacetylation ≥ 85%)

[0072] Glycerin 8g

[0073] Lactic acid amount

[0074] Purified water was added to 100g.

[0075]Preparation method: In an environment with a cleanliness of 100,000, take 80ml of purified water, add chitosan with a molecular weight of 90,000, stir and add an appropriate amount of lactic acid to make the reactant form a gel, and make the gel If the pH value is 4.0-4.5, add glycerin and stir evenly, degas, fill in an aluminum-plastic hose and seal it, and further sterilize it with cobalt-60 radiation at a dose of 8-9.5KGy to obtain the acne-removing scar shell of the present invention. Polysaccharide gel with a viscosity of 79 Pa.s; or degassed and filled in a vial, sealed, and further sterilized at 121°C for 15 minutes to obtain the acne-removing chitosan gel of the present...

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Abstract

The invention relates to chitosan gel for removing acne scars. The chitosan gel for removing acne scars is obtained by mixing chitosan with specific molecular weight and degree of deacetylation, glycerol, acidifier and purified water in a gelatinization manner and then sterilizing. The chitosan gel for removing acne scars, provided by the invention, has good adhesive power, uniform colour and lustre and stability, and has the advantages of good curative effect, safety, natural property, good biocompatibility and the like when used for treating acnes, pimples and seborrheic dermatitis and preventing acne scars. The invention also relates to a preparation method and application of the chitosan gel for removing acne scars.

Description

technical field [0001] The present invention relates to the field of pharmaceutical products, specifically, the present invention relates to a chitosan gel, which is used for the treatment of acne, acne, seborrheic dermatitis, and for preventing the generation of acne scars, etc., and has good curative effect, The invention also relates to its preparation method and medical application. Background technique [0002] Ideal topical pharmaceutical products for treating acne and inhibiting acne scars should have good antibacterial and anti-inflammatory properties, safety, biocompatibility, and ease of use, while being easy to store and use. [0003] Chitosan (Chitosan), chemically named poly(1,4)-2-amino-2-deoxy-β-D-glucose, is a natural biopolymer obtained after partial or complete deacetylation of chitin. It is the only macromolecular alkaline polysaccharide existing in nature, also known as soluble chitin, chitosan glucosamine, chitosan, and chitosan. It has good biocompatib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/722A61P17/02A61P17/10A61P17/00A61P17/08
Inventor 张耿元赵海静庄灵习白东跃
Owner FUZHOU QIANZHENG PHARMA
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