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Magnetic nano-composite microsphere based on cellulose base template and preparation method and use of magnetic nano-composite microsphere

A composite microsphere and magnetic nanotechnology, which is applied in non-active ingredients medical preparations, inorganic non-active ingredients, pharmaceutical formulations, etc., can solve the problem of low magnetic content, uneven distribution of inorganic magnetic particles, and surface cleanliness of composite microspheres. bad wait

Active Publication Date: 2013-04-10
重庆集凯科技服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composite microspheres prepared by this method have a relatively uniform particle size distribution, and the thinness (thickness) of the organic layer is easy to control, but the magnetic content is low, and the distribution of inorganic magnetic particles in the microspheres is uneven.
At the same time, due to the use of a large number of surfactants and other substances in the preparation process, the surface cleanliness of the composite microspheres is not good
All these problems greatly limit the application and industrialization of magnetic composite microspheres.

Method used

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  • Magnetic nano-composite microsphere based on cellulose base template and preparation method and use of magnetic nano-composite microsphere
  • Magnetic nano-composite microsphere based on cellulose base template and preparation method and use of magnetic nano-composite microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Preparation of ferric oxide / poly-N-isopropylacrylamide-polyacrylic acid magnetic nanocomposite microspheres

[0035] (1) Preparation of poly(N-isopropylacrylamide-polyacrylic acid) nanocapsules: In a 500 mL stirred reactor, 0.20 g of hydroxypropyl cellulose with a number average molecular weight of 100,000 was dissolved in 35 mL of distilled water. After stirring at room temperature, a clear and transparent solution was obtained. Then add 0.20 g of acrylic acid, 0.1 mol / L of ascorbic acid (VC) solution and hydrogen peroxide (H 2 o2 ) solution, reacted for 2 hours at 38 ℃ to obtain a milky white hydroxypropyl cellulose-polyacrylic acid colloidal dispersion; 0.15 g of methylene bisacrylamide and 0.05 g of surfactant sodium dodecyl sulfate (SDS) were blended and dissolved in 15 mL of distilled water, and the above solution was added dropwise to the hydroxypropyl cellulose-polyacrylic acid dispersion, React at 35°C for 6-8 hours to obtain a hydroxypropyl cell...

Embodiment 2

[0038] Example 2: Preparation of ferric oxide / poly-N-isopropylacrylamide-polyacrylic acid magnetic nanocomposite microspheres

[0039] (1) Preparation of poly-N-isopropylacrylamide-polyacrylic acid nanocapsules: the process is the same as in Example 1 (1).

[0040] (2) Preparation of Fe3O4 / polyN-isopropylacrylamide-polyacrylic acid magnetic composite microspheres: the above-mentioned polyN-isopropylacrylamide-polyacrylic acid nanocapsule powder was prepared to a concentration of 1.0 mg / mL Take 10 mL of this solution and add 5.0 mg of ferric chloride and ferrous chloride respectively. After standing at room temperature for 24 hours, centrifuge to obtain poly-N-isopropylacrylamide adsorbed with iron ions. - Precipitation of polyacrylic acid nanocapsules. Then the obtained precipitate was redispersed in 20 mL of distilled water, and when the temperature was raised to 50 °C, 75 mL of sodium hydroxide solution with a concentration of 0.15 mg / mL was added dropwise, N 2 React und...

Embodiment 3

[0042] Example 3: Preparation of ferric oxide / poly-N-isopropylacrylamide-polyacrylic acid magnetic nanocomposite microspheres

[0043] (1) Preparation of poly-N-isopropylacrylamide polyacrylic acid nanocapsules: the process is the same as in Example 1 (1).

[0044] (2) Preparation of Fe3O4 / polyN-isopropylacrylamide-polyacrylic acid magnetic nanocomposite microspheres: the above-mentioned polyN-isopropylacrylamide-polyacrylic acid nanocapsule powder was prepared at a concentration of 1.0 mg / mL of nanocapsule solution, take 10 mL of this solution and add 7.5 mg of ferric chloride and ferrous chloride respectively, and after standing at room temperature for 24 hours, perform centrifugation to obtain poly(N-isopropylpropylene) with iron ions adsorbed Precipitation of amide-polyacrylic acid nanocapsules. Then the obtained precipitate was redispersed in 20 mL of distilled water, and when the temperature was raised to 50 °C, 75 mL of sodium hydroxide solution with a concentration...

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Abstract

The invention discloses a magnetic nano-composite microsphere based on a cellulose base template and a preparation method and the use of the magnetic nano-composite microsphere. The magnetic nano-composite microsphere comprises a hollow poly-N-isopropyl acrylamide-polyacrylic nanocapsule and is loaded with Fe3O4 magnetic particles; and the average size of the composite microsphere is 200 to 2,000 nanometers. The preparation method comprises the following steps: a natural polymer hydroxy propyl cellulose-polyacrylic colloidal particle is taken as a template to obtain a hollow poly-N-isopropyl acrylamide-polyacrylic nanocapsule by precipitation polymerization; and then, Fe3O4 inorganic magnetic particles are loaded to the nanocapsule by an electrostatic self-assembly method and an in-site reduction method to prepare a Fe3O4 / poly-N-isopropyl acrylamide-polyacrylic magnetic nano-composite microspher. The composite microsphere has not only a certain of ferromagnetic property but also relatively high drug loading efficiency and good in-vitro release effect on water-soluble drugs, so that the composite microsphere can be applied to the field of biomedicines and biochemical engineering as a targeted drug delivery carrier.

Description

[0001] technical field [0002] The present invention relates to magnetic nanocomposite microspheres based on cellulose-based templates, and as targeted drug carriers. [0003] Background technique [0004] With the rapid development of nanotechnology, nanomaterials, especially magnetic nanoparticles, have aroused great research interest in the field of biomedicine. Magnetic nanoparticles are a class of intelligent nano-magnetic materials, which not only have many characteristics unique to polymer nanomaterials, such as small particle size, large specific surface area, and high coupling capacity, but also have the magnetic responsiveness and superparamagnetism of magnetic substances. , can be gathered and positioned under a constant magnetic field, and absorb electromagnetic waves to generate heat under an alternating magnetic field. Using these properties, magnetic nanoparticles are used in biomarking and separation, magnetic resonance imaging (MRI), tissue repair, drug d...

Claims

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Application Information

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IPC IPC(8): A61K47/32A61K47/02C08F120/06C08F220/54
Inventor 陈莹南静娅储富祥王春鹏
Owner 重庆集凯科技服务有限公司
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