Safe carrier for seed viruses of inactivated vaccine for foot-and-mouth disease and application thereof

Abstract

This invention relates to a safe carrier for the seed viruses of inactivated vaccine for the foot-and-mouth disease and the application thereof. Different serum-type seed viruses for producing the inactivated vaccines for the foot-and-mouth disease safely are constructed on the basis of the carrier. The constructed embedded viruses retain the advantage of good adaptability of the classic vaccine virus strain cell, overcome the defect of low matching performance of the antigen through the structural protein inserted into the epidemic virus strain and can save virus quickly to produce the inactivated vaccine for foot-and-mouth disease. The A or Asia I or O type different virus-strain embedded viruses which are constructed through the carrier are less virulent and have good bio-security. Because the viruses are short of the protein L, the virulence of the viruses can not become stronger under the natural condition, and the pathogenicity of the viruses on the neonatal rat, pig or cow is reduced greatly or the viruses are not pathogenic. The carrier is highly safe, can not cause the foot-and-mouth disease and is highly practical.

Description

technical field [0001] The invention relates to a safe seed virus carrier of an inactivated foot-and-mouth disease vaccine and its application, that is, the safe production seed virus of an inactivated foot-and-mouth disease vaccine of different serotypes is constructed on the basis of the carrier. It belongs to the field of veterinary biological products. Background technique [0002] Foot-and-mouth disease is an acute, febrile, highly contagious viral disease of artiodactyls caused by foot-and-mouth disease virus. Except for some islands, the disease was widely spread all over the world, causing huge economic losses to the world's animal husbandry. Countries around the world have invested heavily in controlling and eradicating foot-and-mouth disease. As of May 2007, OIE announced that 59 countries are non-immune. Among the FMD-free countries, parts of 9 countries are non-immune FMD-free areas, and 7 countries or regions are immune to FMD-free countries. Foot-and-mouth di...

AI Technical Summary

Problems solved by technology

Formaldehyde is the inactivator used in the foot-and-mouth disease inactivated vaccine initially, but because formaldehyde inactivates the coagulation protein, it is easy to cause a large number of viruses to accumulate and inactivate incompletely, and it was later replaced by BEI. Incompletely related, the EU stopped using vaccines in 1990

Developed countries such as Europe and the United States have established vaccine antigen banks for foot-and-mouth disease to prepare emergency vaccines, but they clearly stipulate that inactivated antigens cannot be produced in their own countries. The preserved antigens are all purchased and stored after production and inactivation by manufacturers in Africa and South America.

Images