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Combined trivalent live vaccine for Newcastle disease and infectious chicken bronchitis

A technology for bronchitis and chicken infectivity, applied in the direction of viral antigen components, antibody medical components, antiviral agents, etc., can solve the problems of glandular stomach type IB that cannot be effectively controlled and has not been commercialized, and achieves the effect of reducing side effects

Active Publication Date: 2013-04-03
YEBIO BIOENG OF QINGDAO
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Problems solved by technology

At present, there are many researches on vaccines used to prevent glandular gastric type infectious bronchitis at home and abroad, but none of them have been commercialized yet.
At the same time, due to the large number of IBV serotypes, there has been no attenuated strain with good cross-protection on the market, and the gastric type IB cannot be effectively controlled

Method used

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  • Combined trivalent live vaccine for Newcastle disease and infectious chicken bronchitis
  • Combined trivalent live vaccine for Newcastle disease and infectious chicken bronchitis
  • Combined trivalent live vaccine for Newcastle disease and infectious chicken bronchitis

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Embodiment Construction

[0011] The present invention will be further described below in conjunction with specific embodiments. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

[0012] One, the screening of chicken infectious bronchitis attenuated YB160 strain of the present invention

[0013] Use 10-11 day-old SPF chicken embryos to carry out continuous passage to attenuate the virulence of infectious bronchitis. In each generation, 4 SPF chicken embryos were inoculated through the allantoic cavity, and the attenuation evaluation was carried out for 160 generations. Get 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160 inoculated virus strains to infect 1-day-old SPF chickens. Results There were no dead chick...

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Abstract

The invention relates to a combined trivalent living body vaccine for Newcastle disease and infectious chicken bronchitis. The live vaccine consists of an antigen and a vaccine adjuvant, wherein the antigen comprises an infectious chicken bronchitis virus YB160 strain with a collection code CGMCC No. 6752, an infectious chicken bronchitis virus H120 strain, and a Newcastle disease virus. The prepared combined trivalent vaccine can simultaneously prevent Newcastle disease and infectious chicken bronchitis, and achieves the purpose of preventing two diseases by one injection. Furthermore, the infectious chicken bronchitis virus constituting the vaccine is a low virulent strain obtained by passage for times, thus reducing the side effect caused by the existing infectious bronchitis virus as the antigen.

Description

technical field [0001] The invention belongs to the technical field of poultry vaccines, and in particular relates to a dual-combination trivalent live vaccine for Newcastle disease and infectious bronchitis ("two-combination trivalent vaccine" for short). Background technique [0002] Infectious bronchitis (IB) is an acute and highly contagious respiratory disease caused by infectious bronchitis virus (IBV), characterized by tracheal rales, coughing, and sneezing; It is characterized by a reduction in egg quality and a decrease in egg quality; sick chickens often die due to respiratory, kidney or digestive tract infections. The disease was first reported in the United States by Schalk et al. in 1931, and in 1936 Beach and Hudson determined that the pathogen of the disease was a virus. So far, the disease has been widely prevalent in the world and has brought serious harm to the chicken industry. In my country, Kuang Ronglu (1972) first discovered the disease in Guangdong;...

Claims

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Application Information

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IPC IPC(8): A61K39/295A61K39/215A61K39/17A61P31/14
Inventor 宋新宇孙健朱艳梅邹桂荣韩乃君郭莉莉郭伟伟
Owner YEBIO BIOENG OF QINGDAO
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