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Newcastle disease and infectious bronchitis bivalent live vaccine

A bronchitis and chicken infectious technology, applied in the direction of antibody medical components, medical preparations containing active ingredients, pharmaceutical formulas, etc. Effects of side effects

Active Publication Date: 2014-08-06
YEBIO BIOENG OF QINGDAO +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many researches on vaccines used to prevent glandular gastric type infectious bronchitis at home and abroad, but none of them have been commercialized yet.
At the same time, due to the large number of IBV serotypes, there has been no attenuated strain with good cross-protection on the market, and the gastric type IB cannot be effectively controlled

Method used

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  • Newcastle disease and infectious bronchitis bivalent live vaccine
  • Newcastle disease and infectious bronchitis bivalent live vaccine
  • Newcastle disease and infectious bronchitis bivalent live vaccine

Examples

Experimental program
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Embodiment Construction

[0012] The present invention will be further described below in conjunction with specific embodiments. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

[0013] One, the screening of chicken infectious bronchitis attenuated YB160 strain of the present invention

[0014] Make infectious bronchitis virulent. The 10-11-day-old SPF chicken embryos were used to carry out continuous subculture to attenuate the virulent infectious bronchitis virus. In each generation, 4 SPF chicken embryos were inoculated through the allantoic cavity, and the attenuation evaluation was carried out for 160 generations. Get 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160 inoculated virus strains to infect 1-da...

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Abstract

The invention relates to a newcastle disease and infectious bronchitis bivalent live vaccine which comprises antigens and vaccine assistants, wherein the antigens are an infectious bronchitis virus with a preservation serial number of CGMCC (China General Microbiological Culture Collection Center) No.6752 and a newcastle disease virus. The prepared bivalent vaccine can prevent newcastle diseases and infectious bronchitis, and achieves dual purposes. In addition, the screened infectious bronchitis virus forming the bivalent vaccine is a low virulent strain obtained through passage for many times, and a side effect arising from the existing infectious bronchitis virus as an antigen is reduced.

Description

technical field [0001] The invention belongs to the technical field of poultry vaccines, in particular to a dual live vaccine of Newcastle disease and infectious bronchitis. Background technique [0002] Infectious bronchitis (IB) is an acute and highly contagious respiratory disease caused by infectious bronchitis virus (IBV), characterized by tracheal rales, coughing, and sneezing; It is characterized by a reduction in egg quality and a decrease in egg quality; sick chickens often die due to respiratory, kidney or digestive tract infections. The disease was first reported in the United States by Schalk et al. in 1931, and in 1936 Beach and Hudson determined that the pathogen of the disease was a virus. So far, the disease has been widely prevalent in the world and has brought serious harm to the chicken industry. In my country, Kuang Ronglu (1972) first discovered the disease in Guangdong; by the late 1970s, Zheng Furong et al. in Hangzhou, Wu Zhida et al. in Shanghai, A...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/215
Inventor 杜元钊范根成宋新宇张许科孙进忠荣骏弓
Owner YEBIO BIOENG OF QINGDAO
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