Preparation and application of carbon nano tube-containing thermo-sensitive type gel entrapping for indissolvable drug

Abstract

The invention discloses preparation and application of carbon nano tube-containing thermo-sensitive type gel entrapping for an indissolvable drug. The preparation method comprises the steps of: 1, preparing a poloxamer solution with a volume ratio of 10-40 percent and a chitosan solution with a volume ratio of 0.1-1 percent, mixing the two solutions in a volume ratio of 1:1 to obtain poloxamer / chitosan thermo-sensitive type gel; 2, mixing 0.01-0.1g of carbon nano tube with 20mL of poloxamer / chitosan thermo-sensitive type gel obtained in the step 1, carrying out high-speed shearing to obtain carbon nano tube-containing poloxamer / chitosan thermo-sensitive type gel; and 3, after dissolving the indissolvable drug in a treatment effective dose in a solvent and mixing with the carbon nano tube-containing poloxamer / chitosan thermo-sensitive type gel obtained in the step 1, shearing at a 2000-5000r / min, freeze-drying to obtain nano particles with particle sizes of 400-600nm. The preparation method has the advantages of simpleness in operation, developed process and high yield; and the prepared thermo-sensitive gel is low in critical micelle concentration, is strong in adhering force with focus tissues, high in drug loading capacity, long in drug sustained release time and high in drug effective utilization rate, and is applied to oral administration and injection administration.

Description

Technical field [0001] The invention relates to a method for preparing a novel temperature-sensitive carbon nanotube-containing gel for poorly soluble drugs and its application in oral and injection administration, and belongs to the field of pharmaceutical preparations. Background technique [0002] At present, many of the anti-cancer active compounds are polycyclic compounds, such as camptothecin, paclitaxel, tamoxifen, methotrexate, 5-fluorouracil, etc., and they all have a common characteristic, that is, they are difficult to dissolve in water. Or slightly soluble in water. In order to effectively use these drugs while reducing their toxicity to normal tissue cells, researchers in the field of pharmaceutical preparations implanted them into polymers, which made use of the stable properties, good biocompatibility, and strong solubilization ability of the polymers. Etc. Among the many types of polymers, polysaccharides with excellent biocompatibility and biodegradability have...

AI Technical Summary

Problems solved by technology

However, poloxamers have low encapsulation efficiency and drug loading capacity, high critical micelle concentration, and low stability, which limit their applications.

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