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Compound sweet zinc cream used for treating eczema of infant and preparation method thereof

A technology of infant eczema and compound sweet zinc milk, which is applied in the field of compound sweet zinc milk for the treatment of infant eczema and its preparation, can solve problems such as telangiectasia, inconvenient rubbing of hair and oozing parts, hirsutism, etc.

Inactive Publication Date: 2014-04-09
黄石市第一医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used therapeutic drugs include zinc oxide oil for external use and compound preparations of corticosteroids (such as Yifeisa cream and Perisone cream). Among them, Yifeiza cream and Perisone cream contain hormone components, and long-term use can cause skin atrophy, dryness, Telangiectasia, hirsutism, and even adverse reactions such as leukopenia and abnormal liver and kidney function will seriously affect the growth and development of children
Oil agents such as zinc oxide oil are inconvenient to apply to hair and exudate parts, and are not easy to clean

Method used

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  • Compound sweet zinc cream used for treating eczema of infant and preparation method thereof
  • Compound sweet zinc cream used for treating eczema of infant and preparation method thereof
  • Compound sweet zinc cream used for treating eczema of infant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] a. Take 220g of polyoxyethylene triricinoleate, 40g of isopropyl myristate, 5.0g of vitamin E, 1.0g of menthol, and 30ml of absolute ethanol, mix and stir for 20-30 minutes to prepare A liquid ( i.e. the oil phase);

[0028] b. Take 2.0g of zinc oxide and 2.0g of baicalin, add 622ml of purified water preheated to 50-60°C and stir to dissolve. After 2-3 minutes, it turns orange red, which is liquid B (water phase);

[0029] c. Take 8.0g of dipotassium glycyrrhizinate, add 60ml of butanediol and stir to dissolve, then add 10.0g of nicotinamide, stir and dissolve to obtain liquid C;

[0030] d. Add the above liquid B into liquid C, stir evenly, control the temperature of the solution at 30-35°C, then add the mixture of liquid B and liquid C to liquid A, stir for 20-30 minutes, and then obtain a translucent orange The emulsion is subpackaged to obtain the compound sweetener milk for treating infantile eczema of the present invention.

Embodiment 2

[0032] a. Take 200g of polyoxyethylene triricinoleate, 30g of isopropyl myristate, 2.0g of vitamin E, 1.0g of menthol, and 25ml of absolute ethanol, mix and stir for 20-30 minutes to prepare liquid A;

[0033] b. Take 1.0g of zinc oxide and 1.0g of baicalin, add 683ml of purified water preheated to 50-60°C, stir and dissolve, and obtain orange-red liquid B after 2-3 minutes;

[0034] c. Take 2.0g of dipotassium glycyrrhizinate, add 50ml of butanediol and stir to dissolve, then add 5g of nicotinamide, stir and dissolve to obtain liquid C;

[0035] d. Add the above liquid B into liquid C, stir evenly, control the temperature at 30-35°C, then add it into liquid A and stir for 20-30 minutes to obtain a translucent orange-yellow emulsion, which is then packaged.

Embodiment 3

[0037] a. Take 240g of polyoxyethylene triricinoleate, 50g of isopropyl myristate, 8.0g of vitamin E, 2.0g of menthol, and 35ml of absolute ethanol, mix and stir for 20-30 minutes to prepare liquid A;

[0038] b. Take 4.0g of zinc oxide and 5.0g of baicalin, add 558ml of purified water preheated to 50-60°C and stir to dissolve. After 2-3 minutes, it will turn orange red, which is liquid B;

[0039] c. Take 13g of dipotassium glycyrrhizinate, add 70ml of butanediol and stir to dissolve, then add 15g of nicotinamide, stir and dissolve to obtain liquid C;

[0040]d. Add the above liquid B into liquid C, stir evenly, control the temperature at 30-35°C, then add it into liquid A and stir for 20-30 minutes to obtain a translucent orange-yellow emulsion, which is then packaged.

[0041] The compound sweet zinc milk for treating infantile eczema of the present invention is translucent orange yellow to light brown emulsion;

[0042] Functions and indications: antibacterial, anti-infl...

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Abstract

The invention relates to an externally applied medicine and in particular to compound sweet zinc cream used for treating eczema of an infant and a preparation method thereof. The compound sweet zinc cream provided by the invention mainly comprises dipotassium glycyrrhizinate, baicalin, zinc oxide, nicotinamide, menthol, vitamin E, glycerin three castor acid polyoxyethylene ester 35 and isopropyl myristate; the preparation method of the compound sweet zinc cream comprises the following steps: respectively taking glycerin three castor acid polyoxyethylene ester 35, isopropyl myristate, vitamin E and menthol to prepare solution A; taking zinc oxide and baicalin, adding a right amount of water at the temperature of 50-60 DEG C to prepare solution B, taking dipotassium glycyrrhizinate and nicotinamide to prepare solution C, adding solution B into solution C, stirring to be uniform, then adding mixed solution into the solution A, stirring for 20-30 minutes, so as to obtain semi-transparent orange emulsion, and split charging, so that the compound sweet zinc cream is obtained. Clinical curative effect observation shows that the effective rate of the compound sweet zinc cream prepared by adopting the preparation method provided by the invention for treating the eczema of the infant can reach up to 91%, and the compound sweet zinc cream can be directly applied to skins and hairs and is good in dispersibility, easy to clean and convenient to use.

Description

technical field [0001] The invention relates to a medicine for external use, in particular to a compound sweet zinc milk for treating infant eczema and a preparation method thereof. Background technique [0002] Infant eczema, also known as atopic dermatitis (AD), is a common skin disease in infants and young children. It is more common in infants and young children under the age of 2. It is generally believed that it is related to excessive nutrition, indigestion, food allergy or some external stimuli, Staphylococcus aureus and Candida infection, and genetics. In mild cases, local erythema, papules, and blisters on the skin are accompanied by itching. In severe cases, epidermal erosions, exudation of secretions, severe itching, and often repeated attacks affect the normal health and development of infants. At present, the commonly used therapeutic drugs include zinc oxide oil for external use and compound preparations of corticosteroids (such as Yifeisa cream and Perisone ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/534A61K9/107A61K33/30A61K47/34A61P17/00A61K31/7048A61K31/704A61K31/455A61K31/045A61K31/355
Inventor 刘新庭於席芳张松黄朝卫丁东珅刘挺何美云
Owner 黄石市第一医院
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