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Celecoxib composition, and preparation method and application thereof

A technology of celecoxib and composition, which is applied in the field of orally releasable pharmaceutical composition and its preparation, can solve problems such as increase in tablet hardness, reduce renal side effects, reduce gastrointestinal toxicity, and reduce induction The effect of asthma attack

Inactive Publication Date: 2013-03-06
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] (5), the hardness of tablet increases;

Method used

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  • Celecoxib composition, and preparation method and application thereof
  • Celecoxib composition, and preparation method and application thereof
  • Celecoxib composition, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Capsules are prepared with the following composition:

[0071]

Embodiment 2

[0073] Capsules are prepared with the following composition:

[0074]

Embodiment 3

[0076] Capsules are prepared with the following composition:

[0077]

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Abstract

The invention provides a celecoxib composition which contains one or a plurality of dose units releasable through oral administration. Each dose unit contains 50 to 500 mg of a mixture of a celecoxib D97 particle and one or a plurality of medicinal excipients. The composition can be used for treating or preventing diseases caused by COX-2.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an orally releasable pharmaceutical composition containing an active component Celecoxib (Celebrex, trade name) and a preparation method and application thereof. Background technique [0002] In 1994, G.D Searle Company of the United States applied for a patent in China, the publication number is CN1141630, and the compound 4-[5-(4-methylphenyl-3-(trifluoromethyl-1H-pyrazole-1) was reported in the patent -yl] benzenesulfonamide (celecoxib), and claimed a class of 1,5-diarylpyrazoles and salts thereof and the method for preparing said compound. Celecoxib has the following structure: [0003] [0004] The patent reports that the compound can be used to treat inflammation and diseases related to inflammation. The formulations are in oral dosage forms such as tablets and capsules. [0005] 1998 Simon et al. in Arthritis and Rheumatology, Vol. 41, No. 9, September 19...

Claims

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Application Information

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IPC IPC(8): A61K31/635A61P19/04A61P29/00A61P19/02A61P9/00A61P9/10
Inventor 梅林雨罗振福张晓东郑志超高晶
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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