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Oral calcium supplement for cow-multi-vitamin colloidal calcium emulsion and preparation method of same

A preparation process and technology of calcium emulsion are applied in the field of oral calcium supplementation drugs for dairy cows and their preparation fields, which can solve the problems such as the use mode restricting the scope of application, and achieve the effects of maintaining stability, low technical requirements for personnel, and reducing the number of operations.

Active Publication Date: 2013-02-13
HARBIN WILLHOPE ANIMAL HEALTH CARE PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the colloidal calcium preparations used in domestic veterinary medicine are all injections, and the way of use limits the scope of its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0015] Specific embodiment one: this embodiment prepares multi-dimensional colloidal calcium emulsion according to the following steps:

[0016] (1) Take 0.5 parts by weight of vitamin A, vitamin D 3 3 parts by weight, 0.3 parts by weight of vitamin E, 0.02 parts by weight of butyl hydroxytoluene, 30 parts by weight of emulsifier lecithin, 20 parts by weight of hydrophilic monoglyceride, and 15 parts by weight of Tween-80 are mixed and heated to 85 ° C. Obtain solution 1;

[0017] (2) Dissolve 100 parts by weight of calcium gluconate in 80°C water and stir until clear to obtain solution 2;

[0018] (3) Mix solution 2 with solution 1 and stir for 5 minutes to form primary emulsion;

[0019] (4) Add vitamin B 1 1.5 parts by weight and 0.1 parts by weight of nicotinamide were stirred and dissolved;

[0020] (5) Add 0.05 parts by weight of EDTA-2Na, 0.8 parts by weight of sodium benzoate, and 1 part by weight of methylparaben, add water to 1000ml, emulsify 3 times with a hig...

specific Embodiment approach 2

[0028] Specific embodiment two: the preparation process method of the multi-dimensional colloidal calcium emulsion of the present embodiment is as follows:

[0029] (1) Take 0.3 parts by weight of vitamin A, vitamin D 3 0.1 parts by weight, 0.1 parts by weight of vitamin E, 0.01 parts by weight of butyl hydroxytoluene, 6 parts by weight of emulsifier Span-80, 14 parts by weight of hydrophilic monoglyceride, 12 parts by weight of Tween-80, mixed and heated to 85 °C, solution 1 was obtained;

[0030] (2) Dissolve 120 parts by weight of calcium gluconate in 80°C water and stir until clear to obtain solution 2;

[0031] (3) Mix solution 2 with solution 1 and stir for 5 minutes to form primary emulsion;

[0032] (4) Add vitamin B 1 Stir and dissolve 0.1 parts by weight and 1.5 parts by weight of nicotinamide;

[0033] (5) Add 0.1 parts by weight of EDTA-2Na, 1 part by weight of sodium benzoate, and 0.5 parts by weight of methylparaben, add water to 1000ml, emulsify 3 times wi...

specific Embodiment approach 3

[0034] Specific embodiment three: the preparation process method of the multi-dimensional colloidal calcium emulsion of the present embodiment is as follows:

[0035] (1) Take 0.1 parts by weight of vitamin A, vitamin D 3 1.5 parts by weight, 0.5 parts by weight of vitamin E, 0.02 parts by weight of butyl hydroxytoluene, 3 parts by weight of hydrogenated castor oil of polyoxyethylene ether (40) emulsifier, and 2 parts by weight of lecithin were mixed and heated to 75 ° C to obtain solution 1;

[0036] (2) Dissolve 80 parts by weight of calcium gluconate in 60°C water and stir until clear to obtain solution 2;

[0037] (3) Mix solution 2 with solution 1 and stir for 5 minutes to form primary emulsion;

[0038] (4) Add vitamin B 1 3 parts by weight and 3 parts by weight of nicotinamide are stirred and dissolved;

[0039] (5) Add 0.2 parts by weight of EDTA-2Na, 0.5 parts by weight of sodium benzoate, and 1 part by weight of methylparaben, add water to 1000ml, emulsify 3 tim...

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Abstract

The invention relates to an oral calcium supplement for cow and a preparation procedure of the oral calcium supplement , in particular to a multi-vitamin colloidal calcium emulsion and a preparation procedure thereof. The drug substance of the multi-vitamin colloidal calcium emulsion provided by the invention comprises the following components: 0.1-0.5 parts by weight of vitamin A, 0.1-3 parts by weight of vitamin D3, 0.1-0.5 parts by weight of vitamin E, 5-65 parts by weight of emulsifier, 80-120 parts by weight of calcium gluconate, 0.1-3 parts by weight of vitamin B10, 0.1-3 parts by weight of nicotinamide, 0.01-0.02 parts by weight of butylated hydroxytoluene, 0.05-0.2 parts by weight of EDTA-2Na, 0.5-1.0 parts by weight of sodium benzoate and 0.5-1.0 parts by weight of methylparaben. The raw materials is mixed, emulsified through a high-pressure homogenizer, filtered, filled and capped or sealed to get oral emulsions. The multi-vitamin colloidal calcium emulsion has the advantages of definite curative effect, convenience in use, small stress and low cost.

Description

technical field [0001] The invention relates to an oral calcium supplement for dairy cows and a preparation process thereof, in particular to a "multidimensional gelatinous calcium" emulsion and a preparation process for oral calcium supplementation for dairy cows. Background technique [0002] Calcium is a drug widely used in veterinary clinics for dairy cows. It is often used in combination with vitamin D to improve rickets, chondrosis, and postpartum paralysis. Clinically commonly used calcium carbonate, calcium chloride, calcium gluconate, calcium lactate and so on. Calcium carbonate is often made into powder and taken orally to supplement calcium; one dose, 30-120g for horses and cattle. Calcium chloride has a strong bitter taste and is often made into injections. Because of its strong irritation, it is only suitable for intravenous injection; intravenous injection, one dose, 5-15g for horses and cattle. Calcium gluconate, odorless, tasteless, soluble in water, often ...

Claims

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Application Information

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IPC IPC(8): A61K31/593A61K31/191A61K31/07A61K31/51A61K31/355A61K31/455A61K9/107A61P3/14
Inventor 秦国栋胡海权李文超时国辉
Owner HARBIN WILLHOPE ANIMAL HEALTH CARE PROD CO LTD
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