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Hollowed-out membrane used as hernia patch and preparation method thereof

A patch and hernia technology, which is applied in the application field of biomedical materials, can solve the problems of scattered thread ends, easy fluffing, and twisted hernia patch, and achieves the effects of good fit, small footprint, and low equipment investment.

Inactive Publication Date: 2013-02-13
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a hollowed-out diaphragm used as a hernia patch and its method to solve the problems of the existing hernia patch in the prior art, which are easy to fluff after cutting, the thread ends are scattered, and the shrinkage of the scar will cause the hernia patch to be twisted. The preparation method is a hernia patch with a single-layer film hollow structure and a preparation method thereof, and the hernia patch has good mechanical properties and biocompatibility

Method used

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  • Hollowed-out membrane used as hernia patch and preparation method thereof
  • Hollowed-out membrane used as hernia patch and preparation method thereof

Examples

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Effect test

Embodiment 1

[0032](1) Take polyethylene (PE) as a raw material, and make a film by melt casting at a temperature of 250°C.

[0033] (2) Biaxially stretch the PE nascent film, the stretching ratio is 6 times, and the final thickness is 0.2mm.

[0034] (3) Use the machine engraving method to punch holes in the film. The graphic design of the holes is rectangular, the width is 2mm, the aspect ratio is 2, and the edge width between the holes is 0.8mm, such as figure 2 shown.

[0035] (4) The hollowed-out film was flattened and heat-set at 90°C for 30 minutes to obtain a hollowed-out hernia patch with a tensile strength of 30 MPa and an elongation at break of 10%. It can be tailored appropriately according to actual needs during clinical application.

Embodiment 2

[0037] (1) Take polyethylene (PE) as a raw material, and make a film by melt casting at a temperature of 150°C.

[0038] (2) Biaxially stretch the PE nascent film, the stretching ratio is 1 times, and the final thickness is 1.0mm.

[0039] (3) The film is perforated by machine engraving. The graphic design of the hole is rectangular, the width is 1mm, the aspect ratio is 5, and the edge width between the holes is 0.2mm.

[0040] (4) The hollowed-out film was flattened and heat-set for 60 minutes at a temperature of 50°C to obtain a hollowed-out hernia patch with a tensile strength of 21 MPa and an elongation at break of 50%. It can be tailored appropriately according to actual needs during clinical application.

Embodiment 3

[0042] (1) Take polyethylene (PE) as a raw material, and make a film by melt casting at a temperature of 200 °C.

[0043] (2) Biaxially stretch the PE nascent film, the stretching ratio is 3 times, and the final thickness is 0.4mm.

[0044] (3) Use the machine engraving method to punch holes in the film. The graphic design of the holes is rectangular, the length is 20mm, the aspect ratio is 4, and the edge width between the holes is 5mm.

[0045] (4) Flatten and heat-set the hollowed-out film for 40 minutes at a temperature of 70°C to obtain a hollowed-out hernia patch with a tensile strength of 26 MPa and an elongation at break of 20%. It can be tailored appropriately according to actual needs during clinical application.

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Abstract

The invention discloses a hollowed-out membrane used as a hernia patch and a preparation method thereof. The hollowed-out membrane used as the hernia patch is a high-polymer membrane with holes, and the high-polymer membrane with the holes is used as the hernia patch; and the thickness of the high-polymer membrane is 0.05 to 1.0 millimeter. The preparation method comprises the following steps of: (1) preparing a high-polymer material into a primary membrane by a melting casting method; (2) performing two-way stretching on the primary membrane; (3) punching the holes in the surface of the membrane by a machine carving method; and (4) flattening and performing heat setting to obtain the hollowed-out membrane used as the hernia patch. The hollowed-out membrane has high mechanical property and biocompatibility. And the method for preparing the single-layer hollowed-out membrane for the hernia patch is simple and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the application field of biomedical materials, and relates to a hollow-out diaphragm used as a hernia patch and a preparation method thereof. Background technique [0002] In daily life, the loss, damage or failure of human tissues and organs is very common, which poses a serious threat to people's health and life. For a long time, people have been exploring and researching materials and biotechnology, with the purpose of solving relevant problems in medicine, ensuring human health, and serving the prevention, diagnosis, treatment and rehabilitation of diseases. [0003] A hernia is when a part of a human tissue or organ leaves its original site and enters another site through a gap, defect or weak part of the body. Hernia is a multiple disease, especially the elderly and children have a higher prevalence rate. Because hernia can cause multiple diseases, it constitutes a serious threat to people's health and life. If the her...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/00A61L27/16A61L27/18A61L27/56
CPCA61F2/0063
Inventor 杨庆郯志清沈新元吴文华吉亚丽张佩华王文祖
Owner DONGHUA UNIV
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