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Preparation method of titanium implant surface with micro-nano composite structure

A micro-nano composite structure, titanium implant technology, applied in the field of medical material manufacturing, can solve the problem that there are not many methods for constructing nano-scale structures, etc.

Active Publication Date: 2015-04-15
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are many methods for endowing implant surfaces with microscale and nanoscale structures respectively, but few methods for constructing nanoscale structures on top of microscale structures

Method used

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  • Preparation method of titanium implant surface with micro-nano composite structure
  • Preparation method of titanium implant surface with micro-nano composite structure
  • Preparation method of titanium implant surface with micro-nano composite structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Sand blasting: 40-60 mesh corundum is used for titanium implants with a smooth surface, and is sprayed evenly for 60 seconds under a pressure of 5 bar. After spraying, the implants are cleaned with acetone, ethanol and pure water under ultrasonic conditions for 15 minutes. , and then washed with a large amount of pure water and blown dry with nitrogen. Obtain large fluctuations of tens of microns to tens of microns.

[0018] (2) Oxalic acid etching: The implants after sand blasting were directly placed in a fully dissolved oxalic acid solution with a mass concentration of 37.5% in a boiling water bath for 60 minutes, then cleaned with a large amount of water, and dried with nitrogen.

[0019] (3) Secondary acid etching: put the above-mentioned oxalic acid-treated implants into H2O with a volume ratio of 1:1 2 SO 4 (mass concentration 98%) and H 2 o 2 (mass concentration 30%) mixed solution, at room temperature for 60 minutes. After the treatment, it is directly...

Embodiment 2

[0021] (1) Sandblasting: The implants with smooth surface are sprayed with 20-40 mesh emery for 60 seconds under the pressure of 5 bar. After spraying, the implants are cleaned with acetone, ethanol and pure water under ultrasonic conditions for 15 minutes. Then wash with a large amount of pure water and blow dry with nitrogen. Obtain large fluctuations of tens of microns to tens of microns.

[0022] (2) Oxalic acid etching: The dried implants were directly placed in a fully dissolved oxalic acid solution with a mass concentration of 37.5% in a boiling water bath for 60 minutes, and cleaned with a large amount of pure water.

[0023] (3) Secondary acid etching: put the implant treated above into H 2 SO 4 (mass concentration 98%) and H 2 o 2 (mass concentration 30%) mixed solution, at room temperature for 90 minutes. After the treatment, it is directly washed with a large amount of water to obtain a nano-scale undulating structure on the original micro-pore structure, ther...

Embodiment 3

[0025] (1) Sand blasting: 80-100 mesh corundum is used for the smooth surface of the implant, and it is evenly sprayed for 60 seconds under the pressure of 5 bar. The sprayed implant is cleaned with acetone, ethanol and pure water under ultrasonic conditions for 15 minutes respectively Then wash with a large amount of pure water and blow dry with nitrogen. Obtain large fluctuations of tens of microns to tens of microns.

[0026] (2) Oxalic acid etching: The dried implants were directly placed in a fully dissolved oxalic acid solution with a mass concentration of 37.5% for 30 minutes in a boiling water bath, and then cleaned with a large amount of pure water.

[0027] (3) Secondary acid etching: put the implant treated above into H 2 SO 4 (mass concentration 98%) and H 2 o 2 (mass concentration 30%) mixed solution, at room temperature for 90 minutes. After the treatment, it is directly washed with a large amount of water to obtain a nano-scale undulating structure on the o...

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Abstract

The invention provides a preparation method of a titanium implant surface with a micro-nano composite structure. The preparation method comprises the following steps: (1) performing blast sanding and ultrasonic processing on a smooth implant surface, then washing with water, and drying; (2) processing the implant surface in an oxalic acid solution for 30-240 min, then washing with water, and drying, wherein the concentration of the oxalic acid solution is 30% to saturation; and (3) taking a mixed acid solution of H2SO4 with the concentration of 98% and H2O2 with the concentration of 30% for processing, and then washing with water to obtain the titanium implant surface with the micro-nano composite structure. According to the preparation method of the titanium implant surface with the micro-nano composite structure, disclosed by the invention, the implant surface with the micro-nano composite structure is obtained by performing a secondary etching on a micron-structure surface processed by sand blast and oxalic acid, and compared to the micron-structure surface, titanium implant surface is provided with a microstructure with more levels, which is capable of providing more comprehensive environment signals for cell growth and tissue regeneration; and the titanium implant surface with the micro-nano composite structure has super-hydrophilicity and the protein adsorption capability is remarkably enhanced, which are of a great significance to further improving the surface biological activity of implants.

Description

technical field [0001] The invention belongs to the technical field of medical material manufacturing, and describes a method for preparing the surface of a titanium implant with a micro-nano composite structure. technical background [0002] Since the theory of osseointegration was put forward in the middle of the 20th century, the research and application of implants has made significant progress; because of the support of artificial tooth roots, implant restoration does not need to grind away healthy adjacent teeth, and has high chewing efficiency, less foreign body sensation, and no damage to the Adjacent teeth are strong and durable, and can achieve good aesthetics and functional restoration effects in the case of free end loss and full mouth loss that cannot be achieved by conventional fixed restorations. the third set of teeth". Implant technology has become a routine treatment method for the treatment of dentition defects / missing, and is accepted by more and more pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23F1/16A61L27/50
Inventor 李晓东罗巧洁黄颖
Owner ZHEJIANG UNIV
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