Tolfenamic acid injection and preparation method and application thereof

A technology of tolfenamic acid and injection, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of unstable injections, unstable liquid preparations, and tolfenamic acid. Poor acid solubility and other problems, to achieve the effect of long storage time, good stability and high clarity

Active Publication Date: 2013-02-06
QINGDAO AGRI UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Tolfenamic acid has poor solubility and is unstable when prepared into a liquid preparation. The present invention proposes a solution to solve the problem of unstable injections. For

Method used

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  • Tolfenamic acid injection and preparation method and application thereof
  • Tolfenamic acid injection and preparation method and application thereof
  • Tolfenamic acid injection and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Add 40g of tolfenamic acid to 300g of N-methylpyrrolidone, heat at 60-80°C to dissolve tolfenamic acid, cool, and set aside; add 20g of sodium benzoate and 1g of lidocaine to another 200ml of water for injection, dissolve, and set aside Mix the solution; add water for injection to a total volume of 1000ml, stir for 10 minutes, add NaOH to adjust the pH of the solution to 9.5; filter, pot, and sterilize at 100°C for 30 minutes to obtain.

Embodiment 2

[0067] Add 20g of tolfenamic acid into 100g of N-methylpyrrolidone, heat at 60-80°C to dissolve the tolfenamic acid, cool, and set aside; take 200ml of water for injection, add 10g of sodium benzoate and 1.5g of lidocaine, dissolve, and Mix the spare solution; add water for injection to the full volume of 1000ml, stir for 10 minutes, add NaOH to adjust the pH of the solution to 8.5; filter, pot, sterilize at 100°C for 30min, and you are ready.

Embodiment 3

[0069] Add 100g of tolfenamic acid into 200g of N-methylpyrrolidone, heat at 60-80°C to dissolve tolfenamic acid, cool, and set aside; add 30g of sodium benzoate and 1g of lidocaine to another 200ml of water for injection, dissolve, and set aside Mix the solution; add water for injection to the full amount of 1000ml, stir for 10 minutes, add NaOH to adjust the pH of the solution to 10; filter, pot, and sterilize at 100°C for 30min to obtain.

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Abstract

The invention discloses a tolfenamic acid injection and a preparation method and application thereof. The tolfenamic acid injection disclosed by the invention comprises a main drug, a cosolvent, a pH regulator, a preservative agent and a local analgetic agent. The tolfenamic acid injection disclosed by the invention is safe and convenient to use and controllable in quality; the preparation process of the tolfenamic acid injection is stable, suitable for industrial production and low in cost; and the tolfenamic acid injection enriches veterinary clinical drugs and has obvious effect if being used for treating arthritis, arthritic pain and surgical pain of dogs, cats and the like.

Description

technical field [0001] The invention relates to the field of veterinary preparations, in particular to a tolfenamic acid injection and a preparation method thereof. Background technique [0002] In recent years, with the improvement of people's living standards, the demand for pet breeding has also increased, and the vast market space has accelerated the rapid development of the breeding industry and the pet industry. With the rapid development of the breeding industry and the pet industry, the inflammation and pain caused by the treatment of pet diseases have attracted more and more attention from pet owners. As pets gradually increase in people's hearts, the health of pets has become more and more draw people's attention. How to reduce the pain caused by pet treatment or illness, many anti-inflammatory and analgesic drugs have appeared on the market to reduce the damage caused by pet injuries. According to statistics, there are at least 100 million pets (heads) in China,...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/196A61K47/22A61P19/02A61P29/00A61K31/167
Inventor 郝智慧刘元元张瑞丽贾德强付海宁王艳玲崔亮亮
Owner QINGDAO AGRI UNIV
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