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Method for refining cefodizime sodium at high yield, high cleanliness and high purity

The technology of cefodizime sodium and purification method, which is applied to the field of compounds in the field of medical technology, can solve the problems of improper control of the production process, unsatisfactory drug purity and the like, and achieves the effects of low cost, improved purity and high purity

Active Publication Date: 2013-01-30
TIANJIN GREENPINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, in some cases, due to improper control of the production process, the purity of the drug did not meet the requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A purification method for high-yield, ultra-clean and high-purification ceftizime sodium, the purification method for high-yield, ultra-clean and high-purification cefodizime sodium sequentially comprises: raw material preparation pretreatment, synthesis of cefodizime sodium, Sodium purification and ultra-high-clean purification post-processing steps; it is characterized in that, the above-mentioned raw material preparation pretreatment, the synthesis of cefodizime sodium, the purification of cefodizime sodium and the post-processing steps of ultra-high-clean purification are carried out specifically as follows:

[0032]

[0033] (1) Pretreatment of described raw material preparation: first, ethanol, diethyl ether, ethyl chloroacetate, deionized water, triethylamine and the ceftizin acid compound of formula (II) are added to the sealed mixing reactor successively Evenly stirring at low speed, two spiral stirring rollers are arranged in the center of the inner bottom...

Embodiment 2

[0039] A purification method for high-yield, ultra-clean and high-purification ceftizime sodium, the purification method for high-yield, ultra-clean and high-purification cefodizime sodium sequentially comprises: raw material preparation pretreatment, synthesis of cefodizime sodium, Sodium purification and ultra-high-clean purification post-processing steps; it is characterized in that, the above-mentioned raw material preparation pretreatment, the synthesis of cefodizime sodium, the purification of cefodizime sodium and the post-processing steps of ultra-high-clean purification are carried out specifically as follows:

[0040]

[0041] (1) Pretreatment of described raw material preparation: first, ethanol, diethyl ether, ethyl chloroacetate, deionized water, triethylamine and the ceftizin acid compound of formula (II) are added to the sealed mixing reactor successively Evenly stirring at low speed, two spiral stirring rollers are arranged in the center of the inner bottom...

Embodiment 3

[0047] A purification method for high-yield, ultra-clean and high-purification ceftizime sodium, the purification method for high-yield, ultra-clean and high-purification cefodizime sodium sequentially comprises: raw material preparation pretreatment, synthesis of cefodizime sodium, Sodium purification and ultra-high-clean purification post-processing steps; it is characterized in that, the above-mentioned raw material preparation pretreatment, the synthesis of cefodizime sodium, the purification of cefodizime sodium and the post-processing steps of ultra-high-clean purification are carried out specifically as follows:

[0048]

[0049](1) Pretreatment of described raw material preparation: first, ethanol, diethyl ether, ethyl chloroacetate, deionized water, triethylamine and the ceftizin acid compound of formula (II) are added to the sealed mixing reactor successively Evenly stirring at low speed, two spiral stirring rollers are arranged in the center of the inner bottom ...

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Abstract

The invention relates to a method for refining cefodizime sodium at high yield, high cleanliness and high purity. Through special design of process steps and special optimization of relevant parameters after raw material preparation and pretreatment, synthesis of cefodizime sodium, purification of cefodizime sodium and ultrahigh-cleanliness purification, the defect of difficulty in obtaining a high-purity and high-yield compound by using a general purifying and separating method is overcome, product quality is optimized, toxic and side effects are reduced, process operation is easy, high yield, high product purity and low cost are achieved, and the method is suitable for industrial production; and the purity of a product is further increased through recrystallization, so that a higher-quality product is obtained, and the safety of clinical administration is guaranteed.

Description

technical field [0001] The invention relates to compounds in the technical field of medicine, in particular to a preparation process for the synthesis and purification of cefodizime sodium, and more specifically to a method for refining cefodizime sodium with high yield, ultra-clean and high purification. Background technique [0002] In the last two decades, the chemical name of cefodizime sodium is: (6R, 7R)-7-[(2-amino-4-thiazolyl)-(methoxyimino)acetamido]-3-[[ (5-carboxymethyl-4-methyl-2-thiazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2 - Formic acid disodium salt, molecular weight: 628.64; [0003] Cefodizime sodium is a semi-synthetic third-generation cephalosporin, which has antibacterial activity against Gram-positive and negative bacteria, is stable against β-lactamase, and is extremely stable against cephalosporinase and penicillinase. Clinically, it is mainly used for pneumonia, bronchitis, pharyngitis, tonsillitis, pyelonephritis, urinary tract...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/36C07D501/04C07D501/12
Inventor 郑林海沈载宽
Owner TIANJIN GREENPINE PHARMA
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