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Preparation technology of integrated novel preparation of xiaoqinglong gypsum decoction

A new dosage form and integrated technology, which is applied in the field of preparation of new integrated dosage forms of Xiaoqinglongjiashigao Decoction, achieves the effect of wide target distribution and strong slow and controlled release performance

Inactive Publication Date: 2013-01-30
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts

Method used

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preparation example Construction

[0051] The preparation production method of the present invention comprises the following steps:

[0052]Firstly, take each Chinese herbal decoction piece for pretreatment, weigh it, put it into a pulverizer and pulverize it to 80-200 mesh, and then use a supersonic airflow to pulverize it to 1-10 microns to obtain micron powders of different Chinese medicines for future use. Take 60% ephedra, white peony root, cassia twig, asarum, and roasted licorice micron powder, mix and soak with 6-12 times the amount of 30%--90% alcohol aqueous solution for 1-2 days, reflux extraction 3 times, extract water-soluble, Alcohol-soluble and ester-soluble three effective drug ingredients are recycled to obtain extracts for future use. Take 60% dried ginger, schisandra, pinellia micron powder, and use ultrasonic dispersive extraction equipment to disperse and extract respectively. spare. The traditional Chinese medicine extract obtained above is ground by a nano ball mill for 4-16 hours to ob...

Embodiment 1

[0054] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0055] The composition of the raw materials used to make the active ingredients is——

[0056] 10 parts of ephedra, 10 parts of white peony root, 10 parts of cassia twig, 10 parts of asarum, 10 parts of roasted licorice, 10 parts of dried ginger, 12 parts of schisandra, 12 parts of pinellia, and 12 parts of gypsum.

[0057] The manufacturing process is as follows: in a GMP10000 class clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed in a ratio of 4:2:2:2, and part of the hard capsules are used in the first part of the "Chinese Pharmacopoeia" of the 2010 edition. Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with automatic capsule filling machines to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pa...

Embodiment 2

[0059] The following raw materials are prepared according to the aforementioned method: water decoction concentrate, nanoliposome, nanoemulsion, and microemulsion.

[0060] The composition of the raw materials used to make the active ingredients is——

[0061] 10 parts of ephedra, 10 parts of white peony root, 10 parts of cassia twig, 10 parts of asarum, 10 parts of roasted licorice, 10 parts of dried ginger, 12 parts of schisandra, 12 parts of pinellia, and 12 parts of gypsum.

[0062] The manufacturing process is as follows: in a GMP10000 class clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion are mixed according to the ratio of 4:2:2:2, and a preparation of the 2010 edition of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packa...

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Abstract

The invention relates to a preparation technology of an integrated novel preparation of xiaoqinglong gypsum decoction, comprising the following herbs as effective ingredients: 10 weight parts of ephedra, 10 weight parts of white peony root, 10 weight parts of cassia twig, 10 weight parts of as arum, 10 weight parts of prepared radix licorice, 10 parts of dried ginger, 12 weight parts of fructus schizandrae, 12 weight parts of pinellia ternate, and 12 weight parts of gypsum. The preparation process comprises the following steps: conducting supersonic airflow grinding, alcohol and aqua abstraction, supersonic shattering extraction, decocting for concentration, supersonic spray drying, nanogrinding, high-pressure homogenization, nanoparticle preparation, etc. According to the invention, the advantages of multi-synergy and multi-targets reflected in nanocarrier combined technology are utilized herein; after large-scale production, the production cost can be greatly reduced, the product quality can be greatly raised, and the drug targeting and slow releasing action are improved; the decoction preparation disclosed herein can be taken internally and externally and can be respectively taken for 4 periods of time according to midnight-midday ebb flow and qi and blood flow rules of body body; the decoction preparation disclosed herein can be prepared into a film-forming agent and a transdermal agent, can be respectively applied on different parts of human body according to the midnight-midday ebb flow and qi and blood flow rules of human body, and can be adsorbed directly through skins.

Description

technical field [0001] The invention relates to a novel Xiaoqinglong plus gypsum decoction integrated dosage form, and also relates to a preparation technology for a new Xiaoqinglong plus gypsum decoction integrated dosage form. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxidation, reduction and other reactions...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/00A61P11/00A61K33/06
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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