Long-acting donepezil percutaneous absorption sticking agent

A technology of donepezil and absorption enhancer, which is applied in the field of medicine to achieve long-lasting curative effect, long-lasting and stable curative effect, and improved percutaneous penetration

Inactive Publication Date: 2013-01-30
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there is no patent report on the impact of synergistic accelerators on the transdermal penetration of drugs in donepezil patches. The present invention finds that the combination of surfactant compounds and other accelerators can produce synergistic acceleration of drugs.

Method used

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  • Long-acting donepezil percutaneous absorption sticking agent
  • Long-acting donepezil percutaneous absorption sticking agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 0.25g donepezil free base, 0.0125g Lecithin, 0.0125g Propylene glycol was dissolved in 3.0 g of ethyl acetate, then added 4.725g DuroTak® 87-9301 pressure-sensitive adhesive of National Starch Company, mixed evenly by magnetic stirring for 2 hours, coated on a 75 μm thick anti-adhesive layer, dried at 20°C, 40°C, and 80°C, and then used as a backing with a thickness of 75 μm to 85 μm Composite with polyethylene layers, prepared into an area of ​​60cm 2 pressure-sensitive adhesive dispersion type patch.

Embodiment 2

[0027] Dissolve 0.5g of donepezil free base, 0.125g of lecithin, and 0.125g of propylene glycol in 3.0g of ethyl acetate, then add 4.5g of DuroTak® 87-9301 pressure-sensitive adhesive from National Starch Co. On the thick anti-adhesive layer, after drying at 20°C, 40°C, and 80°C, it is then compounded with a backing layer polyethylene with a thickness of 75 μm to 85 μm to prepare an area of ​​60 cm 2 pressure-sensitive adhesive dispersion type patch.

Embodiment 3

[0029] 0.75g donepezil free base, 0. 25g Lecithin, 0. 25g Propylene glycol was dissolved in 3.0 g of ethyl acetate, then added 3.75g DuroTak® 87-9301 pressure-sensitive adhesive of National Starch Company, mixed evenly by magnetic stirring for 2 hours, coated on a 75 μm thick anti-adhesive layer, dried at 20°C, 40°C, and 80°C, and then used as a backing with a thickness of 75 μm to 85 μm Composite with polyethylene layers, prepared into an area of ​​60cm 2 pressure-sensitive adhesive dispersion type patch.

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Abstract

The invention belongs to the technical field of medicines, and particularly provides a long-acting donepezil percutaneous absorption sticking agent. The long-acting donepezil percutaneous absorption patch agent consists of a back lining layer, a drug-containing pressure-sensitive glue layer and an anti-sticking layer, wherein the long-acting donepezil percutaneous absorption sticking agent comprises 5-15 parts of main drug donepezil, 70-95 parts of pressure-sensitive glue and 0.5-15 parts of percutaneous absorption accelerant. The long-acting donepezil percutaneous absorption sticking agent is characterized in that the ingredients of a film selected by the back lining layer comprises polyethylene, polyester and ethylvinylacetate. The donepezil percutaneous absorption sticking agent provided by the invention is stable and durable in curative effect, and each sticking agent has 5 days of effective function. The long-acting donepezil percutaneous absorption sticking agent is characterized in that the back lining layer capable of providing maximum drug-permeable quantity is adopted. The long-acting donepezil percutaneous absorption sticking agent provided by the invention is good in percutaneous permeability, durable and stable in curative effect, and good in skin feeling.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a long-acting donepezil transdermal absorption patch with good transdermal permeability, long-lasting and stable curative effect and good skin feeling. Background technique [0002] With the acceleration of the aging process of the world's population, the incidence of Alzheimer's disease is increasing year by year. As the sixth deadly disease in human beings, it has brought a heavy burden to social and economic development. As my country gradually enters an aging society and the country pays more attention to the elderly, the development of drugs for Alzheimer's disease is currently attracting attention. [0003] Donepezil is a second-generation cholinesterase inhibitor developed by Japan Eisai Pharmaceutical Co., Ltd., and it is currently the chemical drug of choice for anti-senile dementia. Clinical studies have shown that donepezil hydrochloride can significantl...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/445A61K47/32A61K47/34A61P25/28
Inventor 方亮张亚琼权鹏
Owner SHENYANG PHARMA UNIVERSITY
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