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Traditional Chinese medicine preparation containing aconitum sungpanense alkaloid

A technology of aconitum pine and traditional Chinese medicine preparations is applied in the field of traditional Chinese medicine preparations containing alkaloids of aconitum serrata, can solve problems such as dependence and addiction, and achieve the effects of stable quality, easy operation and obvious pain relief

Inactive Publication Date: 2013-01-16
GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biggest disadvantage of this drug is that long-term use can produce dependence and addiction
Therefore, it is imperative to study a kind of intolerance-resistant and body-dependent analgesics. Up to now, there has not been any data research on the effective part of Songpanaconitum alkaloids with the effective part as the research object, and there is no Clinical application of traditional Chinese medicine preparations made with high content of aconitum alkaloids as active ingredients

Method used

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  • Traditional Chinese medicine preparation containing aconitum sungpanense alkaloid
  • Traditional Chinese medicine preparation containing aconitum sungpanense alkaloid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 A traditional Chinese medicine preparation containing aconitum aconitum, which is a conventional traditional Chinese medicine preparation made from 0.01% aconitum aconitum alkaloid extract—aconitum aconitum alkaloid extract and 99.99% pharmaceutical excipients by weight percentage Dosage formulations.

[0040] in:

[0041] Songpan aconitum alkaloid extract is prepared as follows:

[0042] ⑴ Add ammonia reagent and ethanol with a mass concentration of 40% to the Aconitum aconitum medicinal material that has been crushed and passed through a 60-mesh sieve, and then fully stir, and then ultrasonically extract for 60 minutes at a temperature of 70°C and a power of 500W to obtain the extract A ; The mass-volume ratio (kg / ml) of Songpanaconitum to ammonia reagent is 1:1; the mass-volume ratio (kg / ml) of Songpanaconitum to ethanol is 1:10.

[0043] The extract A is suction-filtered under the condition of 0.07MPa to obtain the filtrate, and the filtrate is conce...

Embodiment 2

[0045] Example 2 A kind of traditional Chinese medicine preparation containing aconitum aconitum, the preparation is a conventional traditional Chinese medicine prepared by 40% aconitum aconitum alkaloid extract—aconitum aconitum alkaloid extract and 60% pharmaceutical excipients by weight percentage Dosage formulations.

[0046] in:

[0047] Songpan aconitum alkaloid extract is prepared as follows:

[0048] ⑴ Add ammonia reagent and ethanol with a mass concentration of 95% to the Aconitum aconitum medicinal material that has been crushed and passed through a 60-mesh sieve, and then fully stir, and ultrasonically extract for 30 minutes at a temperature of 80°C and a power of 500W to obtain the extract A ; The mass-volume ratio (kg / ml) of Songpanaconitum to ammonia reagent is 1:2; the mass-volume ratio (kg / ml) of Songpanaconitum to ethanol is 1:40.

[0049] The extract A is suction-filtered under the condition of 0.09MPa to obtain the filtrate, and the filtrate is concen...

Embodiment 3

[0051] Example 3 A traditional Chinese medicine preparation containing aconitum aconitum, which is a traditional Chinese medicine preparation made from 0.1% aconitum aconitum alkaloid extract—aconitum aconitum alkaloid extract and 99.9% pharmaceutical excipients by weight percentage Dosage formulations.

[0052] in:

[0053] Songpan aconitum alkaloid extract is prepared as follows:

[0054] ⑴Add ammonia reagent and ethanol with a mass concentration of 50% to the Aconitum aconitum medicinal material that has been crushed and passed through a 60-mesh sieve, and then fully stir, and ultrasonically extract for 45 minutes at a temperature of 75°C and a power of 500W to obtain the extract A The mass-volume ratio (kg / ml) of Songpanaconitum medicinal material to ammonia reagent is 1:1.5; the mass-volume ratio (kg / ml) of Songpanaconitum medicinal material to the ethanol is 1:25.

[0055] The extract A is subjected to suction filtration under the condition of 0.08MPa to obtain th...

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Abstract

The invention relates to a traditional Chinese medicine preparation containing aconitum sungpanense alkaloid. The preparation is of a conventional traditional Chinese medicine preparation formulation prepared from, by weight, 0.01-40% of aconitum sungpanense alkaloid extract and 60-99.99% of pharmaceutic adjuvants by the conventional process, wherein the aconitum sungpanense alkaloid extract refers to aconitum sungpanense alkaloid extractum or aconitum sungpanense alkaloid dry extract powder. The traditional Chinese medicine preparation containing the aconitum sungpanense alkaloid is stable in quality, easy to control and applicable to clinical pain management.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine preparation containing aconitum aconitum. Background technique [0002] Songpan Aconitum is a plant of the genus Aconitum in the family Ranunculaceae. It is mainly distributed in Gansu, Qinghai, Sichuan, Shaanxi, Ningxia, Shanxi and other places. It is used in the folk to treat pain caused by bruises, rheumatism, and rheumatoid arthritis. Its chemical The ingredients are mainly a variety of alkaloids, and mainly diterpene alkaloids, which are the main active ingredients of Songpan aconitum, and their pharmacological activities are mainly manifested in analgesic, sedative, antipyretic, anti-inflammatory and other aspects , and no tolerance and physical dependence. [0003] Alkaloids are a class of basic nitrogen-containing compounds, which mostly exist in the form of salts in nature. At present, the extraction and purification methods of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61P29/00
Inventor 张喜民王小芳邓月婷卢英任一杰张政
Owner GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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