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A kind of preparation method and application of cinnamon total polyphenol extract

A technology of total polyphenols and extracts, which is applied in the field of cinnamon total polyphenols extracts, can solve the problems of not many polyphenols in cinnamon and the lack of suitable industrial production materials, so as to achieve stable existence, safety and Effectiveness, the effect of reducing toxic and side effects

Inactive Publication Date: 2016-05-18
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] At present, there are not many published data on the separation and purification of cinnamon polyphenols, and there is no data suitable for industrial production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The total polyphenol extract of cinnamon was prepared by warm soaking method and purified by macroporous adsorption resin HPD-100C:

[0036] After crushing 500g of cinnamon, use 50% ethanol aqueous solution as solvent, extract three times at 50°C, the amount of ethanol solution is 5L, 4L and 3L respectively, and the extraction time is 3 hours, 3 hours and 2 hours respectively, filter and combine to obtain the extracted liquid. Concentrate the extract under reduced pressure until it has almost no alcohol smell, add 1 times the amount of water to dilute the concentrated solution, stir to form a suspension, let it stand, remove the sediment, and use macroporous adsorption resin HPD-100C for adsorption, first use 2 times Resin amount (V / W) water elution removes polar impurities, and then elutes with 5 times of resin amount (V / W) 50% ethanol, collects the eluent, concentrates under reduced pressure and reclaims ethanol, and vacuum-dries to obtain Cinnamon Total Polyphenol E...

Embodiment 2

[0040] The total polyphenol extract of cinnamon was prepared by warm soaking method and purified by macroporous adsorption resin D101:

[0041] Take 500g of cinnamon and pulverize two parts, add 60% ethanol solution and extract three times under the conditions of 40°C (1) and 60°C (2). hours and 2 hours, filtered and combined to obtain the extract. Concentrate the extract under reduced pressure until it has almost no alcohol smell, add 2 times the amount of water to dilute the concentrated solution, stir to form a suspension, let it stand, remove the sediment, and use macroporous adsorption resin D101 for adsorption, first use 2 times the amount of resin (V / W) of water eluting to remove polar impurities, then eluting with 4 times the amount of resin (V / W) 60% ethanol, collecting the eluate, concentrating under reduced pressure and reclaiming ethanol, vacuum drying, to obtain Cinnamon Total Polyphenol Extract.

[0042] The result is as follows:

[0043] (1) The total weight ...

Embodiment 3

[0046] Extraction by percolation method, purification of macroporous adsorption resin D4020 to prepare cinnamon total polyphenols extract:

[0047] After taking 1 kg of cinnamon and pulverizing it, add 2 L of 50% ethanol solution and mix well, place it in a sealed container for 20 minutes, then put it into a percolation cylinder, then add 6 L of 50% ethanol solution, and place it for 24 hours, so that the solvent can fully penetrate and diffuse, and then carry out percolation. Collect percolate. Concentrate the percolation liquid under reduced pressure until it has almost no alcohol smell, add 1.5 times the amount of water to dilute the concentrated solution, stir to form a suspension, let it stand, remove the sediment and use macroporous adsorption resin D4020 for adsorption, first use 1.5 times the amount of resin Volume (V / W) of 10% ethanol solution elutes to remove polar impurities, and then elutes with 5 times of resin volume (V / W) 50% ethanol, collects the eluate, concen...

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Abstract

The invention discloses a cinnamon total polyphenol extract which is characterized in that the content of cinnamon total polyphenol is hihger than 50 percent, the content of impurity coumarin is lower than 0.5 percent, and the content of cinnamaldehyde is lower than 5 percent in percentage by weight. The cinnamon total polyphenol is extracted from cinnamon and prepared through the purification of a macroreticular resin column, the preparation method is simple, the extraction efficiency is high, the production cost is low, the safety is high, and the cinnamon total polyphenol extract is suitable for industrial production. The cinnamon total polyphenol extract can be prepared into oral tablets, orally disintegrating tablets, lozenge, dispersing tablets, hard capsules, soft capsules, sustained release medication, granular formulation, pills, dripping pills, oral liquid, dry suspension and other pharmaceutical preparation for curing and preventing diabetes mellitus and complicating diseases thereof.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to an effective part extracted from Chinese medicine cinnamon, and also relates to a preparation method of the effective part and its medical use. Specifically, it relates to a cinnamon total polyphenol extract, which is obtained by extracting with ethanol and purifying with a macroporous adsorption resin, and can be prepared into a pharmaceutical preparation for treating and preventing diabetes and its complications. Background technique [0002] Diabetes is a widespread disease, and its incidence is increasing every year. There are currently about 125 million diabetics in the world, and it has become one of the three major contemporary difficult diseases. At present, there are about 40 million diabetic patients in my country, and the development of diabetic population is tending to be younger. In addition, diabetes itself has many complications, such as high bloo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A61K36/54A61P31/10
Inventor 卢欣王春丽
Owner 天津市聚星康华医药科技有限公司
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