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Gambogic acid colon-specific controlled release tablet and preparation method thereof

A technology of colon positioning and gambogic acid, applied in the field of medicine, can solve problems such as toxicity

Inactive Publication Date: 2013-01-16
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are still many synthetic azo compounds that have not been used clinically. One of the important reasons is the toxicity of these azo compounds to the human body.

Method used

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  • Gambogic acid colon-specific controlled release tablet and preparation method thereof
  • Gambogic acid colon-specific controlled release tablet and preparation method thereof
  • Gambogic acid colon-specific controlled release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Prescription

[0018] Core:

[0019]

[0020]

[0021] Coating:

[0022]

[0023] (2) Preparation method

[0024] Tablet core: Weigh the prescription amount of gambogic acid, lactose and sodium carboxymethyl starch through an 80-mesh sieve, mix well, add 7% sodium carboxymethyl cellulose aqueous solution to make soft material; sieve to make granules, 60 Dry at ℃ for 3 hours, sieving and granulating, add prescription amount of talcum powder, mix well and press tablets.

[0025] Coating: Weigh the prescription amount of konjac gum and hydroxypropyl methylcellulose that has passed through an 80 mesh sieve, add the prescription amount of talc and mix them evenly, and press them with a 10mm die to make coated tablets.

Embodiment 2

[0027] (1) Prescription

[0028] Core:

[0029]

[0030]

[0031] Coating:

[0032]

[0033] (2) Preparation method

[0034] Tablet core: Weigh the prescription amount of gambogic acid, starch and sodium carboxymethyl starch through an 80-mesh sieve, mix well, add 5% sodium carboxymethyl cellulose aqueous solution to make soft material; sieve to make granules, 60 Dry at ℃ for 2 hours, sieving and granulating, add prescription amount of talcum powder, mix well and then press tablets.

[0035] Coating: Weigh the prescribed amount of pectin and hydroxypropyl methylcellulose that have passed through an 80-mesh sieve, add the prescribed amount of talc and mix them evenly, and press them with a 10mm die to make coated tablets.

Embodiment 3

[0037] (1) Prescription

[0038] Core:

[0039]

[0040] Coating:

[0041]

[0042]

[0043] (2) Preparation method

[0044] Tablet core: Weigh the prescription amount of gambogic acid, starch and sodium carboxymethyl starch through an 80-mesh sieve, mix well, add 5% sodium carboxymethyl cellulose aqueous solution to make soft material; sieve to make granules, 60 Dry at ℃ for 3 hours, sieving and granulating, add prescription amount of talcum powder, mix well and press tablets.

[0045] Coating: Weigh the prescribed amount of pectin and hydroxypropyl methylcellulose that have passed through an 80-mesh sieve, add the prescribed amount of talc and mix them evenly, and press them with a 10mm die to make coated tablets.

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PUM

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Abstract

The invention relates to a gambogic acid colon-specific controlled release tablet and a preparation method thereof. The colon-specific controlled release tablet comprises a tablet core and a coating layer; the tablet core comprises the following material in percentage by weight: 1 to 60 percent of gambogic acid, 2 to 95 percent of diluent adjuvant, 2 to 20 percent of disintegration adjuvant, 1 to 20 percent of adhesion adjuvant, and 0.1 to 5 percent of lubricating adjuvant; and the coating layer comprises the following material in percentage by weight: 15 to 80 percent of polysaccharide compound, 15 to 80 percent of adhesion adjuvant, and 0.2 to 5 percent of lubricating adjuvant. The polysaccharide compound of the coating layer preferably adopts one of pectin and konjac glucomannan. The preparation method comprises the steps of tablet core preparation and coating layer preparation. The gambogic acid colon-specific controlled release tablet can accurately transfer drug to colon, improves the treatment effect of colon cancer, reduces the side effect, and improves the compliance of patients.

Description

Technical field [0001] The invention relates to a colon-positioned controlled release tablet of gambogic acid and a preparation method thereof, and belongs to the technical field of medicine. Background technique [0002] Colon cancer is a common malignant tumor of the digestive tract that occurs in the colon. The most common sites are the rectum and the junction of the rectum and the sigmoid colon. According to the world epidemiological survey, colon cancer has the highest incidence rate in North America, Western Europe, Australia, New Zealand and other places, ranking the top two visceral tumors. With the improvement of people's living standards and changes in dietary structure, the incidence rate is year by year. Upward trend. [0003] About half of the patients with colon cancer have metastasis and recurrence after surgery. Except for some early-stage patients, patients at the late stage and after surgical resection require chemotherapy. Therefore, chemotherapy is a very impo...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K9/22A61K31/352A61P35/00A61P1/00
Inventor 李小强曹蔚侯颖刘笑笑招明高
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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