Composition for improving human sperm motility and quality

A technology of activity and composition, applied in the direction of drug combination, plant raw materials, organic active ingredients, etc., can solve the problems of uncertain ingredients and content, large and single therapeutic dose, and achieve significant safety effects

Active Publication Date: 2013-01-02
欣安贝药业科技盐城有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, the clinical preparations for improving and improving the motility and quality of human sperm are relatively single, and the treatment dose is relatively large, such as: zinc sulfate, vitamin E, etc. are prone to side effects after long-term use, and Chinese herbal medicines or Chinese patent medicines also contain various vitamins and minerals. Substance, but the composition and content are uncertain

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Premixed raw materials vitamin B12 (0.6g), vitamin C (200g), natural vitamin E (50g), folic acid (0.26g), zinc gluconate (50g), selenium-enriched yeast (25g), fructose, citric acid, arginine Acid etc. (674.14g), 2000 pieces of composition made by the above preparation method, 0.5g for each piece. After 5 days of adaptive feeding, the male rats were randomly divided into 4 groups, 15 in each group. The rats in the normal group ate the common feed, and the rats in the three sample groups ate the common feed respectively and were given 0.5g / kg and 1.0g / kg by gavage at the same time. kg, 2.5g / kg of the above composition, after 30 days, blood was collected from the aorta of the rats in each group, and the testes were dissected simultaneously. See Table 2. Statistical analysis of the test results showed that the testicular weight, sperm count and activity percentage of rats in each of the three sample groups were significantly higher than those in the normal group (P<0.01). In ...

Embodiment 2

[0041] Compound formula vitamin B12 (0.3mg), vitamin C (50mg), natural vitamin E (25mg), folic acid (1.3mg), zinc gluconate (45mg), selenium-enriched yeast (15mg), fructose (50mg), citric acid ( 15mg) and arginine powder (196.7mg) to make compound powder, 0.5g per dose, choose 35 cases of infertility patients between the ages of 23 and 38 with a course of infertility of more than 2 years and 20 cases of normal males in the control group for 90 days Clinical Observation. Once a day, 2 doses of the composition preparation were given to infertile patients, and they were taken orally for 90 consecutive days, and computer-assisted semen analysis (CASA) was performed at the end of each month. After taking it for 60 days and 90 days, see Table 3, the patient’s sperm quality improved significantly , Compared with before taking, the patient's sperm density, sperm motility rate, (a+b) grade sperm, sperm survival rate, and percentage of forward motile sperm were all significantly improve...

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PUM

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Abstract

The invention discloses a composition for improving human sperm motility and quality, which comprises zinc, selenium, vitamin E, folic acid, vitamin B12, vitamin C, fructose, and citric acid. The composition of the invention is safe and effective for long-term administration, and has significant safety.

Description

technical field [0001] The invention relates to a composition, in particular to a composition for improving the motility and quality of human sperm. Background technique [0002] In the past 50 years, the quality of human sperm has been declining, mainly manifested in the decline of sperm motility and viability, and the increase of the incidence of sperm deformity. It has been reported that zinc is directly involved in the process of sperm production, maturation, activation, and capacitation. The main effects of zinc on sperm motility are: (1) Zinc can delay the lipid oxidation of the cell membrane to maintain cell structure stability and physiological communication. Permeability, so that sperm have good motility. The good motility of sperm is mainly maintained by mitochondria and "9+2 structure". (2) During ejaculation, sperm absorb zinc in the seminal plasma and combine with the sulfhydryl group of cell chromatin, so as to prevent chromatin from premature depolymerizatio...

Claims

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Application Information

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IPC IPC(8): A61K36/064A61P15/08A61K31/315A61K31/355A61K31/519A61K31/714A61K31/375A61K31/7004
Inventor 陈浩
Owner 欣安贝药业科技盐城有限公司
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