Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for purifying edulinine

A technology of milocarpine and purification method, which is applied in chemical recovery, organic chemistry, bulk chemical production, etc., to achieve the effects of high efficiency, short extraction time, and short preparation period

Inactive Publication Date: 2012-12-19
NANJING ZELANG MEDICAL TECH
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In modern research, there are very few reports on the addition of stimulantine, and the related research on this substance is still in its infancy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 2:

Embodiment 2

[0021] Example 3:

Embodiment 3

[0023] Example 4:

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a method for purifying edulinine. The method comprises the steps that common rue herb is taken as a raw material, ground and soaked with alkaline alcohol for 2-8 hours, the mixture is added into an extraction kettle, supercritical CO2 extraction is adopted, extract is collected and dissolved with acid water, filtration is carried out, the pH of filtrate is regulated to 8-10 through ammonia water, precipitate is subjected to alumina column chromatography to obtain the crude product, a high-speed counter current chromatograph is adopted for separation while taking carbon tetrachloride-methanol-water as a solvent system, and high content of the edulinine is obtained after being dried under reduced pressure. The method is simple, has high yield, can be used for producing products with high purity, and has higher economic value and academic value.

Description

technical field [0001] The present invention relates to a kind of purification method of stannous milocarpine, particularly relate to a kind of application supercritical CO 2 Extraction and high-speed countercurrent chromatography extraction and purification of stannoxine. Background technique [0002] Add tin mirrocarpine is quinoline alkaloid, molecular formula C 16 h 21 NO 4 , white flaky crystals (ethyl acetate), mp.114-117°C. Adding stannous mirrocarpine has strong analgesic and central inhibitory effects, can inhibit the disease-like discharge induced by bicuculline in the CA1 area of ​​rat hippocampal slices, and resist the epilepsy-induced effect of bicuculline. Can be used as analgesic, central sedative and antiepileptic agent. [0003] Jiaxi Mirrocarpine is derived from the whole herb of Rutaceae Rutaceae, which is the whole herb of the Rutaceae plant Rutaceae. Smelly grass has the effects of dispelling wind and clearing heat, promoting blood circulation and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D215/22
CPCY02P20/54Y02P20/582
Inventor 刘东锋
Owner NANJING ZELANG MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com