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Medicinal composition comprising albiflorin and arctiin and application

A kind of technology of arctiin and paeoniflorin

Active Publication Date: 2012-12-19
宁波立华制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no literature report on the combination of total glucosides of paeony and arctiin in the treatment of diabetes in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Extraction and purification of total glucosides of paeony

[0028] Take clean and dried Radix Paeoniae Alba, crush it, add 10 times the weight of 70% (v / v) ethanol, heat and extract at 65-75°C for 3 times, each time for 3 hours, combine the extracts, filter, and recover the solvent from the filtrate under reduced pressure , concentrated in vacuum into crude extract of Radix Paeoniae Alba; the crude extract of Radix Paeoniae Alba was dissolved in 20 times the weight of 70% (v / v) ethanol, adjusted to pH = 6 with sodium hydroxide solution, and HPD with polystyrene skeleton -300 macroporous adsorption resin to adsorb the solution. After the adsorption is saturated, first absorb the impurities with water until the Molish reaction is negative, and then use 70% (v / v) ethanol with 10 times the amount of resin, at a flow rate of 3 times the amount of resin / hour Elution, recovery of the eluate, concentration, drying, to obtain total glucosides of paeony as light yellow-...

Embodiment 2

[0030] The preparation of embodiment 2 arctiin

[0031] Take clean and dried burdock seeds, crush them, add water 1.5 times the weight of the medicinal material, soak for 8 hours, then add water to extract 3 times, the amount of water added each time is 10 times the weight of the medicinal material, and the extraction time is 1 hour. Combine the extracts, concentrate, and dry. A colorless crystalline powder arctiin was obtained. Calculated on dry basis, arctiin (C 27 h 34 o 11 ) content of more than 95%.

[0032]

Embodiment 3

[0033] Example 3 Effect of total glucosides of paeony combined with arctiin on the viability of islet cells

[0034] SD rats aged 1-3 days were taken out, routinely disinfected, laparotomy was used to expose the operative field, the pancreas was aseptically taken out, the outer omentum and adipose tissue of the pancreas were removed, and rinsed with Hanks solution at 4°C for 2-3 times. Cut the pancreas to 0.5 mm with ophthalmic scissors 3 For small and large tissue fragments, after rinsing with Hanks solution for 3 times, add 5 times the volume of 3g / L type V collagenase (pH 7.4) to mix well, shake and digest in a 37°C water bath for 6-8 minutes. When the digestion solution is turbid, absorb the upper layer of digestion turbid solution after natural precipitation, and stop digestion with 4°C Hanks solution. Add digestive juice to the remaining undigested tissues to continue digestion. Repeat the above operation 4-5 times until the pancreatic tissue is basically digested. Co...

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PUM

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Abstract

The invention discloses a medicinal composition comprising albiflorin and arctiin, wherein the weight ratio of the albiflorin to the arctiin is (0.05 to 0.5):1. The medicinal composition disclosed by the invention can be used for synergically treating the diabetes mellitus by oral administration, particularly can enable diabetics to be recovered and gets rid of the defect that the diabetics need to take medicine for life in the treating process.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition containing total glucosides of paeony and arctiin and its application, in particular to a pharmaceutical composition containing total glucosides of paeony and arctiin capable of curing diabetes patients and its application. Background technique [0002] The incidence of diabetes is still increasing year by year. According to data, diabetes has become the fifth leading cause of death in the world, and is considered to be a non-communicable disease second only to cardiovascular and cerebrovascular diseases and malignant tumors. In 2005, the global diabetic population has expanded to 220 million people. At present, there are no less than 40 million diabetic patients in my country, and many patients are at risk of impaired glucose tolerance. In developing countries, including my country, the adult prevalence rate is relatively high, and the middle-age...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K31/7048A61P3/10
Inventor 王学政鲁俞江尤斌林爱弟陈旦凤陈胜胜杨海玲孙卓亚
Owner 宁波立华制药有限公司
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