Flumatinib mesylate crystal form B and preparation method and use thereof
A technology of flumatinib mesylate and crystal form, which is applied in the field of preparation of drugs for the treatment of chronic myeloid leukemia, and can solve problems such as structural changes, failure to combine with Gleevec, and occurrence of chronic myeloid leukemia patients
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Embodiment 1
[0016] Put 1.0 g of flumatinib mesylate and 100.0 ml of ethyl acetate in a reaction flask, heat to reflux until completely dissolved, naturally cool to room temperature under stirring conditions, stir for 24 hours, precipitate solids, filter, and vacuum dry to obtain Form B.
Embodiment 2
[0018] Put 100 g of flumatinib mesylate and 2,000 ml of isopropanol in a reaction flask, heat to reflux until solid forms an oily substance, naturally cool to room temperature under stirring conditions, stir vigorously for 48 hours, and the oily substance turns into a solid, Filter and dry in vacuo to obtain Form B.
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