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Compound neomycin sulfate composition for treating pet abscess and preparation method of compound neomycin sulfate composition

A technology of neomycin sulfate and erythromycin thiocyanate, which is used in drug combinations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problem that the transdermal accelerator has an insignificant and difficult to achieve transdermal promotion effect. The parasitic parts of pathogens and the problem of antibiotic resistance are easy to produce resistance, so as to achieve the effects of step-by-step mixing, significant curative effect, and enhanced antibacterial effect.

Inactive Publication Date: 2014-06-18
QINGDAO LVMAN BIOLOGICAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, antibacterial drugs are often used in the treatment of this disease. Because antibacterial drugs are prone to drug resistance, the clinical effect will decline after long-term use; however, most of the antibacterial drugs on the market today are single preparations, and the skin penetration promoting effect of the transdermal accelerator is not obvious. , when treating deep infection, it is difficult to reach the parasitic site of the pathogen, and the effect of current therapeutic drugs for this type of disease is not outstanding enough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A kind of preparation method of the compound neomycin sulfate composition for the treatment of pet suppurative sore, carry out as follows: (every part is calculated by 10g)

[0021] (1) Take 500 parts of liquid paraffin by said parts by weight, heat to after melting, and keep stirring;

[0022] (2) Weigh 10 parts of cetyltrimethylammonium bromide, 70 parts of glycerin, 10 parts of neomycin sulfate, 30 parts of erythromycin thiocyanate, and 10 parts of trimethoprim lactate according to the parts by weight , 10 parts of essence, 30 parts of menthol, add 600 parts of distilled water, heat and stir to dissolve until uniform;

[0023] (3) Slowly add (1) to (2) under the condition of stirring, add 4 parts of ethylparaben, add 526 parts of distilled water at the same temperature, stir evenly and cool to obtain a cream.

Embodiment 2

[0025] A kind of preparation method of the compound neomycin sulfate composition for the treatment of pet suppurative sore, carry out as follows: (every part is calculated by 10g)

[0026] (1) Take 600 parts of liquid paraffin by said parts by weight, heat to after melting, and keep stirring;

[0027] (2) Take by weighing 20 parts of cetyltrimethylammonium bromide, 80 parts of glycerol, 20 parts of neomycin sulfate, 40 parts of erythromycin thiocyanate, and 15 parts of trimethoprim lactate by weight. , 20 parts of essence, 40 parts of menthol, add 500 parts of distilled water, heat and stir to dissolve until uniform;

[0028] (3) Slowly add (1) to (2) under the condition of stirring, add 4 parts of ethylparaben, add 465 parts of distilled water at the same temperature, stir evenly and cool to obtain a cream.

Embodiment 3

[0030] A kind of preparation method of the compound neomycin sulfate composition for the treatment of pet suppurative sore, carry out as follows: (every part is calculated by 10g)

[0031] (1) Take 700 parts of liquid paraffin by said parts by weight, heat to after melting, and keep stirring;

[0032] (2) Weigh 30 parts of cetyltrimethylammonium bromide, 90 parts of glycerol, 30 parts of neomycin sulfate, 50 parts of erythromycin thiocyanate, and 20 parts of trimethoprim lactate by weight. , 30 parts of essence, 50 parts of menthol, add 400 parts of distilled water, heat and stir to dissolve until uniform;

[0033] (3) Slowly add (1) into (2) under stirring conditions, add 4 parts of ethylparaben, add 400 parts of distilled water at the same temperature, stir evenly, and cool to obtain a cream.

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Abstract

The invention relates to a compound neomycin sulfate composition for treating pet abscess and a preparation method of the compound neomycin sulfate composition. The composition is prepared by uniformly mixing the following components by weight: 1-3 parts of neomycin sulfate, 3-5 parts of erythromycin thiocyanate, 1-2 parts of trimethoprim lactate, 1-3 parts of cetrimonium bromide, 3-5 parts of piperitol, 50-70 parts of liquid paraffin, 7-9 parts of glycerol, 0.4 part of ethylparaben, 1-3 parts of essence, 80-113 parts of distilled water and the like. The compound neomycin sulfate composition has the beneficial effects that the formula is reasonable, preparation is simple, curative effects are very remarkable, and furthermore, clinical application show that the compound neomycin sulfate composition has special effect for treating pet abscess.

Description

technical field [0001] The invention relates to a compound neomycin sulfate composition for treating pet suppurative sores and a preparation method thereof, belonging to the field of animal medicine, in particular to a compound neomycin sulfate composition for treating pet suppurative sores and a preparation method thereof. Background technique [0002] Pet suppurative sore is a common disease of pets such as dogs and cats. It is an festering skin disease. It mainly manifests as abscesses on the skin. The pustules are the size of grains to mung beans. scar. Severe cases can affect the whole body. Affected pets have loss of appetite, stunted growth and development, and reduced resistance. They may be infected with other diseases and eventually die of sepsis or myocarditis. The morbidity and fatality rates are very high, which brings great economic losses to my country's pet industry. [0003] At present, antibacterial drugs are often used in the treatment of this disease. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/7036A61K31/505A61K9/06A61P31/04A61P17/00
Inventor 周庆福刘文利
Owner QINGDAO LVMAN BIOLOGICAL ENG
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